WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 200133
CAS#: 121268-17-5
Description: Alendronate sodium is the sodium salt of alendronate, a second generation bisphosphonate and synthetic analog of pyrophosphate with bone anti-resorption activity. Alendronate sodium binds to and inhibits the activity of geranyltranstransferase (farnesyl pyrophosphate synthetase), an enzyme involved in terpenoid biosynthesis. Inhibition of this enzyme prevents the biosynthesis of isoprenoid lipids (FPP and GGPP) that are donor substrates of farnesylation and geranylgeranylation during the post-translational modification of small GTPase signalling proteins, which is important in the process of osteoclast turnover. As a result, osteoclast activity is inhibited and bone resorption and turnover are reduced. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
MedKoo Cat#: 200133
Name: Alendronate sodium
CAS#: 121268-17-5
Chemical Formula: C4H18NNaO10P2
Exact Mass:
Molecular Weight: 325.12
Elemental Analysis: C, 14.78; H, 5.58; N, 4.31; Na, 7.07; O, 49.21; P, 19.05
Alendronate sodium trihydrate, purity > 98%, is in stock. The same day shipping out after order is received.
Synonym: Alendronate; Alendronic Acid Monosodium Salt Trihydrate. US brand name: Fosamax; Foreign brand names: Adronat; Alendros; Onclast. Code names: G704650; MK217.
IUPAC/Chemical Name: (4-amino-1-hydroxybutylidene) bisphosphonic acid monosodium salt trihydrate.
InChi Key: DCSBSVSZJRSITC-UHFFFAOYSA-M
InChi Code: InChI=1S/C4H13NO7P2.Na.3H2O/c5-3-1-2-4(6,13(7,8)9)14(10,11)12;;;;/h6H,1-3,5H2,(H2,7,8,9)(H2,10,11,12);;3*1H2/q;+1;;;/p-1
SMILES Code: OC(P([O-])(O)=O)(P(O)(O)=O)CCCN.[H]O[H].[H]O[H].[H]O[H].[Na+]
The following data is based on the product molecular weight 325.12 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Imai K. Alendronate sodium hydrate (oral jelly) for the treatment of osteoporosis: review of a novel, easy to swallow formulation. Clin Interv Aging. 2013;8:681-8. doi: 10.2147/CIA.S37199. Epub 2013 Jun 7. Review. PubMed PMID: 23766643; PubMed Central PMCID: PMC3679967.
2: Ananchenko G, Novakovic J, Tikhomirova A. Alendronate sodium. Profiles Drug Subst Excip Relat Methodol. 2013;38:1-33. doi: 10.1016/B978-0-12-407691-4.00001-0. Review. PubMed PMID: 23668401.
3: Von Schacht E, Dambacher MA, Ringe JD, Dukas L. [Combination of alendronate plus alfacalcidol in the treatment of osteoporosis. Rationale, preclinical data and clinical evidence]. MMW Fortschr Med. 2012 Apr 5;154 Suppl 1:10-21. Review. German. PubMed PMID: 23427364.
4: Hanna J, Bee J, Sataloff RT. Laryngeal ulceration and hemoptysis secondary to inadvertent alendronate overdose: case report and review of the literature. Ear Nose Throat J. 2012 Nov;91(11):484-5. Review. PubMed PMID: 23288794.
5: He D, Yin M, Luo Y, Wei Q. [Research progress of protective effects of alendronate on articular cartilage in osteoarthritis]. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2012 Oct;26(10):1187-90. Review. Chinese. PubMed PMID: 23167100.
6: Emad Y, Ragab Y, El-Shaarawy N, Rasker JJ. Transient osteoporosis of the hip, complete resolution after treatment with alendronate as observed by MRI description of eight cases and review of the literature. Clin Rheumatol. 2012 Nov;31(11):1641-7. doi: 10.1007/s10067-012-2060-y. Epub 2012 Aug 30. Review. PubMed PMID: 22933125.
7: Lin T, Wang C, Cai XZ, Zhao X, Shi MM, Ying ZM, Yuan FZ, Guo C, Yan SG. Comparison of clinical efficacy and safety between denosumab and alendronate in postmenopausal women with osteoporosis: a meta-analysis. Int J Clin Pract. 2012 Apr;66(4):399-408. doi: 10.1111/j.1742-1241.2011.02806.x. Epub 2012 Feb 7. Review. PubMed PMID: 22313934.
8: Gutman D, Golomb G. Liposomal alendronate for the treatment of restenosis. J Control Release. 2012 Jul 20;161(2):619-27. doi: 10.1016/j.jconrel.2011.11.037. Epub 2011 Dec 8. Review. PubMed PMID: 22178594.
9: Kharazmi M, Sjöqvist K, Warfvinge G. Oral ulcers, a little known adverse effect of alendronate: review of the literature. J Oral Maxillofac Surg. 2012 Apr;70(4):830-6. doi: 10.1016/j.joms.2011.03.046. Epub 2011 Aug 4. Review. PubMed PMID: 21816532.
10: Imai K. Vertebral fracture risk and alendronate effects on osteoporosis assessed by a computed tomography-based nonlinear finite element method. J Bone Miner Metab. 2011 Nov;29(6):645-51. doi: 10.1007/s00774-011-0281-9. Epub 2011 Jun 14. Review. PubMed PMID: 21667358.
