DOTMA
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MedKoo CAT#: 555960

CAS#: 104872-42-6

Description: DOTMA is one of the first cationic lipid used for gene transfection. DOTMA is an effective transfection agent in vitro and in vivo. DOTMA carries a positive charge on the surface of liposomes which condenses anionic nucleic acids and promotes efficient interactions between the cell membrane and the liposome.


Chemical Structure

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DOTMA
CAS# 104872-42-6

Theoretical Analysis

MedKoo Cat#: 555960
Name: DOTMA
CAS#: 104872-42-6
Chemical Formula: C42H84ClNO2
Exact Mass: 669.6191
Molecular Weight: 670.589
Elemental Analysis: C, 75.23; H, 12.63; Cl, 5.29; N, 2.09; O, 4.77

Price and Availability

Size Price Availability Quantity
25.0mg USD 150.0 Ready to ship
50.0mg USD 250.0 Ready to ship
100.0mg USD 450.0 Ready to ship
200.0mg USD 750.0 Ready to ship
500.0mg USD 1550.0 Ready to ship
1.0g USD 2450.0 Ready to ship
2.0g USD 4250.0 Ready to ship
5.0g USD 7950.0 2 Weeks
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Related CAS #: 717090-94-3 (cation)   104872-42-6 (chloride)    

Synonym: DOTMA; 1,2-di-O-octadecenyl-3-trimethylammonium propane

IUPAC/Chemical Name: N,N,N-trimethyl-2,3-bis(((Z)-octadec-9-en-1-yl)oxy)propan-1-aminium chloride

InChi Key: LDGWQMRUWMSZIU-LQDDAWAPSA-M

InChi Code: InChI=1S/C42H84NO2.ClH/c1-6-8-10-12-14-16-18-20-22-24-26-28-30-32-34-36-38-44-41-42(40-43(3,4)5)45-39-37-35-33-31-29-27-25-23-21-19-17-15-13-11-9-7-2;/h20-23,42H,6-19,24-41H2,1-5H3;1H/q+1;/p-1/b22-20-,23-21-;

SMILES Code: CCCCCCCC/C=C\CCCCCCCCOCC(OCCCCCCCC/C=C\CCCCCCCC)C[N+](C)(C)C.[Cl-]

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 670.589 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Charbe NB, Amnerkar ND, Ramesh B, Tambuwala MM, Bakshi HA, Aljabali AAA, Khadse SC, Satheeshkumar R, Satija S, Metha M, Chellappan DK, Shrivastava G, Gupta G, Negi P, Dua K, Zacconi FC. Small interfering RNA for cancer treatment: overcoming hurdles in delivery. Acta Pharm Sin B. 2020 Nov;10(11):2075-2109. doi: 10.1016/j.apsb.2020.10.005. Epub 2020 Oct 13. PMID: 33304780; PMCID: PMC7714980.

2: Rezaee M, Oskuee RK, Nassirli H, Malaekeh-Nikouei B. Progress in the development of lipopolyplexes as efficient non-viral gene delivery systems. J Control Release. 2016 Aug 28;236:1-14. doi: 10.1016/j.jconrel.2016.06.023. Epub 2016 Jun 15. PMID: 27317365.

3: Zhang Y, Wang Z, Gemeinhart RA. Progress in microRNA delivery. J Control Release. 2013 Dec 28;172(3):962-74. doi: 10.1016/j.jconrel.2013.09.015. Epub 2013 Sep 25. PMID: 24075926; PMCID: PMC3891846.

4: Zhang S, Xu Y, Wang B, Qiao W, Liu D, Li Z. Cationic compounds used in lipoplexes and polyplexes for gene delivery. J Control Release. 2004 Nov 24;100(2):165-80. doi: 10.1016/j.jconrel.2004.08.019. PMID: 15544865.

5: Ruponen M, Honkakoski P, Rönkkö S, Pelkonen J, Tammi M, Urtti A. Extracellular and intracellular barriers in non-viral gene delivery. J Control Release. 2003 Dec 5;93(2):213-7. doi: 10.1016/j.jconrel.2003.08.004. PMID: 14636726.

6: Morse MA. Technology evaluation: gene therapy (IL-2), Valentis Inc. Curr Opin Mol Ther. 2000 Aug;2(4):448-52. PMID: 11249776.

7: Morse MA. Technology evaluation: VEGF165 gene therapy, Valentis Inc. Curr Opin Mol Ther. 2001 Feb;3(1):97-101. PMID: 11249737.

DOTMA

25.0mg / USD 150.0