Lapatinib ditosylate

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 100946

CAS#: 388082-77-7 (ditosylate)

Description: Lapatinib is a synthetic, orally-active quinazoline with potential antineoplastic activity. Lapatinib reversibly blocks phosphorylation of the epidermal growth factor receptor (EGFR), ErbB2, and the Erk-1 and-2 and AKT kinases; it also inhibits cyclin D protein levels in human tumor cell lines and xenografts. EGFR and ErbB2 have been implicated in the growth of various tumor types. Check for active clinical trials or closed clinical trials using this agent.

Price and Availability


USD 150
USD 650
USD 2650

USD 250
USD 950
USD 3850

USD 450
USD 1450
USD 5950

Lapatinib ditosylate, purity > 98%, is in stock. The same day shipping out after order is received. Note: the estimated shipping out time for order > 700g may be 2 weeks.

Chemical Structure


Theoretical Analysis

MedKoo Cat#: 100946
Name: Lapatinib ditosylate
CAS#: 388082-77-7 (ditosylate)
Chemical Formula: C43H42ClFN4O10S3
Exact Mass:
Molecular Weight: 925.46
Elemental Analysis: C, 55.81; H, 4.57; Cl, 3.83; F, 2.05; N, 6.05; O, 17.29; S, 10.39

Related CAS #: 388082-77-7 (ditosylate)   231277-92-2 (free base)    

Synonym: GSK572016; GSK-572016; GSK 572016; GW2016; GW-2016; GW 2016; Lapatinib; Lapatinib ditosylate; Brand name: Tykerb. CAT#100490B.

IUPAC/Chemical Name: N-(3-chloro-4-((3-fluorobenzyl)oxy)phenyl)-6-(5-(((2-(methylsulfonyl)ethyl)amino)methyl)furan-2-yl)quinazolin-4-amine ditosylate


InChi Code: InChI=1S/C29H26ClFN4O4S.2C7H8O3S/c1-40(36,37)12-11-32-16-23-7-10-27(39-23)20-5-8-26-24(14-20)29(34-18-33-26)35-22-6-9-28(25(30)15-22)38-17-19-3-2-4-21(31)13-19;2*1-6-2-4-7(5-3-6)11(8,9)10/h2-10,13-15,18,32H,11-12,16-17H2,1H3,(H,33,34,35);2*2-5H,1H3,(H,8,9,10)

SMILES Code: O=S(CCNCC1=CC=C(C2=CC3=C(NC4=CC=C(OCC5=CC=CC(F)=C5)C(Cl)=C4)N=CN=C3C=C2)O1)(C)=O.OS(=O)(C6=CC=C(C)C=C6)=O.OS(=O)(C7=CC=C(C)C=C7)=O

Technical Data

Yellow solid powder

>98% (or refer to the Certificate of Analysis)

Safety Data Sheet (MSDS):

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:

Additional Information

Note: Previously we assigned 100490B for Lapatinib ditosylate.
New catalogue# for Lapatinib ditosylat is 100946, which was created on 2/10/2017.
CAT#100490B is the same product as CAT#100946.


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16: Bouchalova K, Cizkova M, Cwiertka K, Trojanec R, Friedecky D, Hajduch M. Lapatinib in breast cancer - the predictive significance of HER1 (EGFR), HER2, PTEN and PIK3CA genes and lapatinib plasma level assessment. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2010 Dec;154(4):281-8. Review. PubMed PMID: 21293538.

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