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MedKoo CAT#: 100230
CAS#: 863127-77-9 (hydrate)
Description: Dasatinib, also known as BMS-354825, is an orally bioavailable synthetic small molecule-inhibitor of SRC-family protein-tyrosine kinases. Dasatinib binds to and inhibits the growth-promoting activities of these kinases. Apparently because of its less stringent binding affinity for the BCR-ABL kinase, dasatinib has been shown to overcome the resistance to imatinib of chronic myeloid leukemia (CML) cells harboring BCR-ABL kinase domain point mutations.
MedKoo Cat#: 100230
Name: Dasatinib monohydrate
CAS#: 863127-77-9 (hydrate)
Chemical Formula: C22H28ClN7O3S
Exact Mass: 487.15572
Molecular Weight: 506.02
Elemental Analysis: C, 52.22; H, 5.58; Cl, 7.01; N, 19.38; O, 9.49; S, 6.34
Related CAS #: 302962-49-8 (free form) 863127-77-9 (hydrate)
Synonym: BMS-354825; BMS 354825; BMS354825; Dasatinib; US brand name: Sprycel.
IUPAC/Chemical Name: N-(2-chloro-6-methylphenyl)-2-((6-(4-(2-hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-yl)amino)thiazole-5-carboxamide monohydrate.
InChi Key: XHXFZZNHDVTMLI-UHFFFAOYSA-N
InChi Code: InChI=1S/C22H26ClN7O2S.H2O/c1-14-4-3-5-16(23)20(14)28-21(32)17-13-24-22(33-17)27-18-12-19(26-15(2)25-18)30-8-6-29(7-9-30)10-11-31;/h3-5,12-13,31H,6-11H2,1-2H3,(H,28,32)(H,24,25,26,27);1H2
SMILES Code: O=C(C1=CN=C(NC2=NC(C)=NC(N3CCN(CCO)CC3)=C2)S1)NC4=C(C)C=CC=C4Cl.[H]O[H]
Related CAS#
863127-77-9 (Dasatinib monohydrate);
302962-49-8 (Dasatinib).
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