Doxorubicin Free Base
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MedKoo CAT#: 100960

CAS#: 23214-92-8 (free base)

Description: Doxorubicin free base, also called doxorubicin, is an anthracycline antibiotic with antineoplastic activity. Approved API for cancer therapeutic use is doxorubicin HCl. Doxorubicin, isolated from the bacterium Streptomyces peucetius var. caesius, is the hydroxylated congener of daunorubicin. Doxorubicin intercalates between base pairs in the DNA helix, thereby preventing DNA replication and ultimately inhibiting protein synthesis. Note: Doxorubicin free base has low solubility in common solvents. The MedKoo original CAT# for this product was 100280a.


Chemical Structure

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Doxorubicin Free Base
CAS# 23214-92-8 (free base)

Theoretical Analysis

MedKoo Cat#: 100960
Name: Doxorubicin Free Base
CAS#: 23214-92-8 (free base)
Chemical Formula: C27H29NO11
Exact Mass: 543.17
Molecular Weight: 543.520
Elemental Analysis: C, 59.66; H, 5.38; N, 2.58; O, 32.38.

Price and Availability

Size Price Availability Quantity
10mg USD 150 Ready to ship
25mg USD 250 Ready to ship
50mg USD 450 Ready to ship
100mg USD 750 Ready to ship
200mg USD 1250 Ready to ship
500mg USD 2650 Ready to ship
1g USD 3850 Ready to Ship
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Related CAS #: 23214-92-8 (free base)   25316-40-9 (HCl)  

Synonym: ADR; chloridrato de doxorrubicina. Adriamycin; Adriacin; Adriblastina; Adriblastine; Adrimedac; DOXOCELL; Doxolem; Doxorubin; Farmiblastina; Rubex. Abbreviations: ADM; Adria; DOX. Code name: FI106;

IUPAC/Chemical Name: (8S,10S)-10-(((2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-7,8,9,10-tetrahydrotetracene-5,12-dione.

InChi Key: AOJJSUZBOXZQNB-TZSSRYMLSA-N

InChi Code: InChI=1S/C27H29NO11/c1-10-22(31)13(28)6-17(38-10)39-15-8-27(36,16(30)9-29)7-12-19(15)26(35)21-20(24(12)33)23(32)11-4-3-5-14(37-2)18(11)25(21)34/h3-5,10,13,15,17,22,29,31,33,35-36H,6-9,28H2,1-2H3/t10-,13-,15-,17-,22+,27-/m0/s1

SMILES Code: O=C1C2=C(O)C(C[C@](C(CO)=O)(O)C[C@@H]3O[C@H]4C[C@H](N)[C@H](O)[C@H](C)O4)=C3C(O)=C2C(C5=C1C=CC=C5OC)=O

Appearance: Deep-red to black solid powder

Purity: >95% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: This product has low solubility in all common solvents.

Shelf Life: >5 years if stored properly

Drug Formulation: This drug may be formulated in DMSO at low concentration.

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info: The original CAT# for this product was 100280a.

Biological target:
In vitro activity:
In vivo activity:

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
This product has low solubility in all common solvents. 0.0 0.00

Preparing Stock Solutions

The following data is based on the product molecular weight 543.52 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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3. Saifutiarova AE, Fedorov YV, Tsvetkov VB, Rustamova DA, Gulakova EN, Chmelyuk NS, Abakumov MA, Aliev TM, Fedorova OA. Photochemical synthesis, intercalation with DNA and antitumor evaluation in vitro of benzo[d]thiazolo[3,2-a]quinolin-10-ium derivatives. Bioorg Chem. 2021 Oct;115:105267. doi: 10.1016/j.bioorg.2021.105267. Epub 2021 Aug 16. PMID: 34426158.

4, Baek MJ, Nguyen DT, Kim D, Yoo SY, Lee SM, Lee JY, Kim DD. Tailoring renal-clearable zwitterionic cyclodextrin for colorectal cancer-selective drug delivery. Nat Nanotechnol. 2023 Aug;18(8):945-956. doi: 10.1038/s41565-023-01381-8. Epub 2023 Apr 27. PMID: 37106052.