WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 555958
Description: WWL-154 is a serine hydrolase inhibitor. Serine hydrolases (SHs) are-one of the largest and most diverse enzyme classes in mammals. They play fundamental roles in virtually all physiol. processes and are targeted by drugs to treat diseases such as diabetes, obesity, and neurodegenerative disorders.
MedKoo Cat#: 555958
Chemical Formula: C18H19N3O5
Exact Mass: 357.1325
Molecular Weight: 357.366
Elemental Analysis: C, 60.50; H, 5.36; N, 11.76; O, 22.38
Synonym: WWL-154; WWL 154; WWL154;
IUPAC/Chemical Name: 4-(4-Methoxyphenyl)-1-piperazinecarboxylic acid, 4-nitrophenyl ester
InChi Key: TULVXRNEEQWFGU-UHFFFAOYSA-N
InChi Code: InChI=1S/C18H19N3O5/c1-25-16-6-2-14(3-7-16)19-10-12-20(13-11-19)18(22)26-17-8-4-15(5-9-17)21(23)24/h2-9H,10-13H2,1H3
SMILES Code: O=C(N1CCN(C2=CC=C(OC)C=C2)CC1)OC3=CC=C([N+]([O-])=O)C=C3
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 357.366 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
Bachovchin DA, Ji T, Li W, Simon GM, Blankman JL, Adibekian A, Hoover H, Niessen S, Cravatt BF. Superfamily-wide portrait of serine hydrolase inhibition achieved by library-versus-library screening. Proc Natl Acad Sci U S A. 2010 Dec 7;107(49):20941-6. doi: 10.1073/pnas.1011663107. Epub 2010 Nov 17. PMID: 21084632; PMCID: PMC3000285.