Psychotridine | CAS#52617-25-1 | Human platelet aggregation inhibitor

Psychotridine
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WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 464407

CAS#: 52617-25-1

Description: Psychotridine is an alkaloid that has been found in P. forsteriana and has diverse biological activities. It inhibits ADP-, collagen-, or thrombin-induced aggregation of washed isolated human platelets with IC50 values of 1.4, 1.4, and 3.9 µM, respectively. Psychotridine (2.5 or 5 µM) is cytotoxic to HTC rat hepatocellular carcinoma cells. It reduces paw licking induced by capsaicin in mice when administered at doses of 0.5, 2.5, or 5 mg/kg.

Chemical Structure

Psychotridine

CAS# 52617-25-1

Instruction

Theoretical Analysis

MedKoo Cat#: 464407
Name: Psychotridine
CAS#: 52617-25-1
Chemical Formula: C55H62N10
Exact Mass: 862.52
Molecular Weight: 863.171
Elemental Analysis: C, 76.53; H, 7.24; N, 16.23

Price and Availability

Size	Price	Availability
10mg	USD -2	2 Weeks
25mg	USD -2	2 Weeks
50mg	USD -2	2 Weeks
100mg	USD -2	2 Weeks
200mg	USD -2	2 Weeks
500mg	USD -2	2 Weeks
2g	USD -2	2 Weeks
1mg	USD 370	2 Weeks
5mg	USD 950	2 Weeks
Bulk inquiry Welcome, Customer: Please do not inquire quote if your intended use is for a patient since our products are for research use and for chemical synthesis use, not for human use . For in-stock products, we listed price in the web page. You may inquire prices for which sizes were not listed. If no price is listed, this means the product is not in stock at the moment, which may be available via custom synthesis. For cost-effective reason, minimum order of 1g is requested (typically very expensive). The lead time is usually 2-4 months. Quote of less than 1g will not be provided. MedKoo may not offer quote for below reasons: (1) current available synthetic method appears to be extremely expensive which is obviously not affordable to most customers; (2) Key raw material to make the product is temporally not available; (3) DEA controlled substances; (4) the product is under patent protection in customer’s country.

Synonym: Psychotridine;

IUPAC/Chemical Name: 1,1',1'',1''',1''''-pentamethyl-2,2',2'',2''',2'''',3,3',3'',3''',3'''',8,8a,8',8'a,8'',8''a,8''',8'''a,8'''',8''''a-icosahydro-1H,1'H,1''H,1'''H,1''''H-3a,7':3'a,3''a:7'',3'''a:7''',3''''a-quinquepyrrolo[2,3-b]indole

InChi Key: DVJSMVZSIBHXAO-UHFFFAOYSA-N

InChi Code: InChI=1S/C55H62N10/c1-61-28-23-51(33-13-6-8-21-41(33)56-46(51)61)35-15-10-16-36-43(35)58-48-53(36,25-30-63(48)3)38-18-12-20-40-45(38)60-50-55(40,27-32-65(50)5)54-26-31-64(4)49(54)59-44-37(17-11-19-39(44)54)52-24-29-62(2)47(52)57-42-22-9-7-14-34(42)52/h6-22,46-50,56-60H,23-32H2,1-5H3

SMILES Code: CN(C1NC2=C3C=CC=C2)CCC13C4=CC=CC5=C4NC6N(C)CCC56C7=CC=CC8=C7NC9N(C)CCC89C%10%11C%12=C(C(C%13%14C%15=C(C=CC=C%15)NC%13N(C)CC%14)=CC=C%12)NC%10N(C)CC%11

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Instruction:

View handling instruction

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 863.17 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Amador TA, Verotta L, Nunes DS, Elisabetsky E. Involvement of NMDA receptors in the analgesic properties of psychotridine. Phytomedicine. 2001 May;8(3):202-6. doi: 10.1078/0944-7113-00025. PMID: 11417913.

2: Jannic V, Guéritte F, Laprévote O, Serani L, Martin MT, Sévenet T, Potier P. Pyrrolidinoindoline alkaloids from Psychotria oleoides and Psychotria lyciiflora. J Nat Prod. 1999 Jun;62(6):838-43. doi: 10.1021/np9805387. PMID: 10395499.

3: Roth A, Kuballa B, Bounthanh C, Cabalion P, Sévenet T, Beck JP, Anton R. Cytotoxic activity of polyindoline alkaloids of Psychotria forsteriana (Rubiaceae) (1). Planta Med. 1986 Dec;(6):450-3. doi: 10.1055/s-2007-969251. PMID: 3494261.

4: Beretz A, Roth-Georger A, Corre G, Kuballa B, Anton R, Cazenave JP. Polyindolinic Alkaloids from Psychotria forsteriana. Potent Inhibitors of the Aggregation of Human Platelets. Planta Med. 1985 Aug;51(4):300-3. doi: 10.1055/s-2007-969496. PMID: 17340518.

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