Noracetildenafil | CAS#949091-38-7 | Sildenafil derivative

Noracetildenafil
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WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 464344

CAS#: 949091-38-7

Description: Noracetildenafil is a derivative of the phosphodiesterase 5 (PDE5) inhibitor sildenafil.

Chemical Structure

Noracetildenafil

CAS# 949091-38-7

Product data Instruction

Theoretical Analysis

MedKoo Cat#: 464344
Name: Noracetildenafil
CAS#: 949091-38-7
Chemical Formula: C24H32N6O3
Exact Mass: 452.25
Molecular Weight: 452.559
Elemental Analysis: C, 63.70; H, 7.13; N, 18.57; O, 10.61

Price and Availability

Size	Price	Availability
10mg	USD -2	2 Weeks
25mg	USD -2	2 Weeks
50mg	USD -2	2 Weeks
100mg	USD -2	2 Weeks
200mg	USD -2	2 Weeks
500mg	USD -2	2 Weeks
2g	USD -2	2 Weeks
1mg	USD 370	2 Weeks
5mg	USD 880	2 Weeks
Bulk inquiry Welcome, Customer: Please do not inquire quote if your intended use is for a patient since our products are for research use and for chemical synthesis use, not for human use . For in-stock products, we listed price in the web page. You may inquire prices for which sizes were not listed. If no price is listed, this means the product is not in stock at the moment, which may be available via custom synthesis. For cost-effective reason, minimum order of 1g is requested (typically very expensive). The lead time is usually 2-4 months. Quote of less than 1g will not be provided. MedKoo may not offer quote for below reasons: (1) current available synthetic method appears to be extremely expensive which is obviously not affordable to most customers; (2) Key raw material to make the product is temporally not available; (3) DEA controlled substances; (4) the product is under patent protection in customer’s country.

Synonym: Noracetildenafil; Demethylhongdenafil;

IUPAC/Chemical Name: 5-(2-ethoxy-5-(2-(4-methylpiperazin-1-yl)acetyl)phenyl)-1-methyl-3-propyl-1,4-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one

InChi Key: BEAXWKCHSPVXQB-UHFFFAOYSA-N

InChi Code: InChI=1S/C24H32N6O3/c1-5-7-18-21-22(29(4)27-18)24(32)26-23(25-21)17-14-16(8-9-20(17)33-6-2)19(31)15-30-12-10-28(3)11-13-30/h8-9,14H,5-7,10-13,15H2,1-4H3,(H,25,26,32)

SMILES Code: O=C1N=C(NC2=C1N(N=C2CCC)C)C3=C(C=CC(C(CN4CCN(C)CC4)=O)=C3)OCC

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Product Data:

Product Data

Instruction:

View handling instruction

Biological target:	Nor-Acetildenafil is an Acetildenafil derivative. Acetildenafil is a synthetic agent which acts as a phosphodiesterase inhibitor.
In vitro activity:	TBD
In vivo activity:	TBD

Preparing Stock Solutions

The following data is based on the product molecular weight 452.56 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:	TBD
In vitro protocol:	TBD
In vivo protocol:	TBD

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

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1: Doi T, Takahashi K, Yamazaki M, Asada A, Takeda A, Kiyota K, Tagami T, Sawabe Y, Yamano T. Characterization of a new illicit phosphodiesterase-type-5 inhibitor identified in the softgel shell of a dietary supplement. J Pharm Biomed Anal. 2018 Nov 30;161:61-65. doi: 10.1016/j.jpba.2018.08.031. Epub 2018 Aug 18. PMID: 30145450.

2: Hu T, Qu X, Kang M, Song Q, Yang L, Zhao Y, Zhang D. [Rapid screening and confirmation of illegally added anti- impotence preparations in health care products by high performance liquid chromatography-high resolution mass spectrometry]. Se Pu. 2015 Aug;33(8):897-901. Chinese. doi: 10.3724/sp.j.1123.2015.03020. PMID: 26749869.

3: Shi F, Guo C, Gong L, Li J, Dong P, Zhang J, Cui P, Jiang S, Zhao Y, Zeng S. Application of a high resolution benchtop quadrupole-Orbitrap mass spectrometry for the rapid screening, confirmation and quantification of illegal adulterated phosphodiesterase-5 inhibitors in herbal medicines and dietary supplements. J Chromatogr A. 2014 May 30;1344:91-8. doi: 10.1016/j.chroma.2013.12.030. Epub 2013 Dec 17. PMID: 24377735.

4: Reepmeyer JC, Woodruff JT. Use of liquid chromatography-mass spectrometry and a chemical cleavage reaction for the structure elucidation of a new sildenafil analogue detected as an adulterant in an herbal dietary supplement. J Pharm Biomed Anal. 2007 Aug 15;44(4):887-93. doi: 10.1016/j.jpba.2007.04.011. Epub 2007 Apr 18. PMID: 17532168.

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