Gadoleic Acid | CAS#29204-02-2 | p53 dsDNA binding activity inhibitor

Gadoleic Acid
featured

WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 464326

CAS#: 29204-02-2

Description: Gadoleic acid is a monounsaturated fatty acid. It inhibits the dsDNA binding activity of p53 when used at a concentration of 1.2 nM. Hepatic levels of gadoleic acid are reduced in rats fed a high-fat or a high-fat high-cholesterol diet and increased in rats fed a high-cholesterol diet.

Chemical Structure

Gadoleic Acid

CAS# 29204-02-2

Instruction

Theoretical Analysis

MedKoo Cat#: 464326
Name: Gadoleic Acid
CAS#: 29204-02-2
Chemical Formula: C20H38O2
Exact Mass: 310.29
Molecular Weight: 310.522
Elemental Analysis: C, 77.36; H, 12.34; O, 10.30

Price and Availability

Size	Price	Availability	Quantity
5mg	USD 850	2 Weeks
Bulk inquiry Welcome, Customer: Please do not inquire quote if your intended use is for a patient since our products are for research use and for chemical synthesis use, not for human use . For in-stock products, we listed price in the web page. You may inquire prices for which sizes were not listed. If no price is listed, this means the product is not in stock at the moment, which may be available via custom synthesis. For cost-effective reason, minimum order of 1g is requested (typically very expensive). The lead time is usually 2-4 months. Quote of less than 1g will not be provided. MedKoo may not offer quote for below reasons: (1) current available synthetic method appears to be extremely expensive which is obviously not affordable to most customers; (2) Key raw material to make the product is temporally not available; (3) DEA controlled substances; (4) the product is under patent protection in customer’s country.

Synonym: Gadoleic Acid; C20:1(9Z); cis-11-Eicosenoic Acid;

IUPAC/Chemical Name: (Z)-icos-9-enoic acid

InChi Key: LQJBNNIYVWPHFW-QXMHVHEDSA-N

InChi Code: InChI=1S/C20H38O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h11-12H,2-10,13-19H2,1H3,(H,21,22)/b12-11-

SMILES Code: CCCCCCCCCC/C=C\CCCCCCCC(O)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Instruction:

View handling instruction

Biological target:
In vitro activity:
In vivo activity:

Solubility Data

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	Ethanol	0.0	0.00

Preparing Stock Solutions

The following data is based on the product molecular weight 310.52 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:
In vitro protocol:
In vivo protocol:

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt* g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1

Volume 1

Concentration 2

Volume 2

1: Kim DS, Maden SK, Burt AA, Ranchalis JE, Furlong CE, Jarvik GP. Dietary fatty acid intake is associated with paraoxonase 1 activity in a cohort-based analysis of 1,548 subjects. Lipids Health Dis. 2013 Dec 12;12:183. doi: 10.1186/1476-511X-12-183. PMID: 24330840; PMCID: PMC3878825.

2: Mikrou T, Pantelidou E, Parasyri N, Papaioannou A, Kapsokefalou M, Gardeli C, Mallouchos A. Varietal and Geographical Discrimination of Greek Monovarietal Extra Virgin Olive Oils Based on Squalene, Tocopherol, and Fatty Acid Composition. Molecules. 2020 Aug 21;25(17):3818. doi: 10.3390/molecules25173818. PMID: 32839421; PMCID: PMC7503666.

3: Turinek M, Bavec M, Repič M, Turinek M, Krajnc AU, Möllers C, Tres A, Bavec F. Effects of intensive and alternative production systems on the technological and quality parameters of rapeseed seed (Brassica napus L. 'Siska'). J Sci Food Agric. 2017 Jun;97(8):2647-2656. doi: 10.1002/jsfa.8088. Epub 2016 Nov 21. PMID: 27739135.

4: Horn PJ, Silva JE, Anderson D, Fuchs J, Borisjuk L, Nazarenus TJ, Shulaev V, Cahoon EB, Chapman KD. Imaging heterogeneity of membrane and storage lipids in transgenic Camelina sativa seeds with altered fatty acid profiles. Plant J. 2013 Oct;76(1):138-50. doi: 10.1111/tpj.12278. Epub 2013 Aug 5. PMID: 23808562.

5: Bobiński R, Mikulska M, Mojska H, Simon M. Comparison of the fatty acid composition of transitional and mature milk of mothers who delivered healthy full-term babies, preterm babies and full-term small for gestational age infants. Eur J Clin Nutr. 2013 Sep;67(9):966-71. doi: 10.1038/ejcn.2013.96. Epub 2013 May 22. PMID: 23695208.

6: Alezones J, Avila M, Chassaigne A, Barrientos V. Caracterización del perfil de ácidos grasos en granos de híbridos de maíz blanco cultivados en Venezuela [Fatty acids profile characterization of white maize hybrids grown in Venezuela]. Arch Latinoam Nutr. 2010 Dec;60(4):397-404. Spanish. PMID: 21866691.

7: Wang ML, Morris JB, Tonnis B, Pinnow D, Davis J, Raymer P, Pederson GA. Screening of the entire USDA castor germplasm collection for oil content and fatty acid composition for optimum biodiesel production. J Agric Food Chem. 2011 Sep 14;59(17):9250-6. doi: 10.1021/jf202949v. Epub 2011 Aug 22. PMID: 21838261.

8: Martínez B, Miranda JM, Nebot C, Rodriguez JL, Cepeda A, Franco CM. Differentiation of farmed and wild turbot (Psetta maxima): proximate chemical composition, fatty acid profile, trace minerals and antimicrobial resistance of contaminant bacteria. Food Sci Technol Int. 2010 Oct;16(5):435-41. doi: 10.1177/1082013210367819. Epub 2010 Oct 18. PMID: 21339162.

9: Oladiji AT, Shoremekun KL, Yakubu MT. Physicochemical properties of the oil from the fruit of Blighia sapida and toxicological evaluation of the oil-based diet in Wistar rats. J Med Food. 2009 Oct;12(5):1127-35. doi: 10.1089/jmf.2008.0219. PMID: 19857079.

10: Pinho RS, Oliveira AF, Silva SI. Potential oilseed crops from the semiarid region of northeastern Brazil. Bioresour Technol. 2009 Dec;100(23):6114-7. doi: 10.1016/j.biortech.2009.06.010. Epub 2009 Jul 3. PMID: 19577461.

11: Muñoz G, Alves E, Fernández A, Ovilo C, Barragán C, Estellé J, Quintanilla R, Folch JM, Silió L, Rodríguez MC, Fernández AI. QTL detection on porcine chromosome 12 for fatty-acid composition and association analyses of the fatty acid synthase, gastric inhibitory polypeptide and acetyl-coenzyme A carboxylase alpha genes. Anim Genet. 2007 Dec;38(6):639-46. doi: 10.1111/j.1365-2052.2007.01668.x. PMID: 18052940.

Your view history

Gadoleic Acid featured