Calcium Dobesilate

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MedKoo CAT#: 413608

CAS#: 20123-80-2

Description: Calcium Dobesilate is a drug used to reduce hemorrhage in diabetic retinopathy.

Chemical Structure

Calcium Dobesilate
CAS# 20123-80-2

Theoretical Analysis

MedKoo Cat#: 413608
Name: Calcium Dobesilate
CAS#: 20123-80-2
Chemical Formula: C12H10CaO10S2
Exact Mass: 417.9341
Molecular Weight: 418.4
Elemental Analysis: C, 34.45; H, 2.41; Ca, 9.58; O, 38.24; S, 15.33

Price and Availability

Size Price Availability Quantity
10.0mg USD 244.0 2 Weeks
50.0mg USD 549.0 2 Weeks
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Synonym: Calcium Dobesilate; Doxium; Nugatex; Toraxine

IUPAC/Chemical Name: Benzenesulfonic acid, 2,5-dihydroxy-, calcium salt


InChi Code: InChI=1S/2C6H6O5S.Ca/c2*7-4-1-2-5(8)6(3-4)12(9,10)11;/h2*1-3,7-8H,(H,9,10,11);/q;;+2/p-2

SMILES Code: O=S(C1=CC(O)=CC=C1O)([O-])=O.O=S(C2=CC(O)=CC=C2O)([O-])=O.[Ca+2]

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 418.4 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Liu J, Li S, Sun D. Calcium Dobesilate and Micro-vascular diseases. Life Sci. 2019 Mar 15;221:348-353. doi: 10.1016/j.lfs.2019.02.023. Epub 2019 Feb 12. PMID: 30769115.

2: Wang Y, Lu YH, Tang C, Xue M, Li XY, Chang YP, Cheng Y, Li T, Yu XC, Sun B, Li CJ, Chen LM. Calcium Dobesilate Restores Autophagy by Inhibiting the VEGF/PI3K/AKT/mTOR Signaling Pathway. Front Pharmacol. 2019 Aug 9;10:886. doi: 10.3389/fphar.2019.00886. PMID: 31447680; PMCID: PMC6696883.

3: Zhang X, Liu W, Wu S, Jin J, Li W, Wang N. Calcium dobesilate for diabetic retinopathy: a systematic review and meta-analysis. Sci China Life Sci. 2015 Jan;58(1):101-7. doi: 10.1007/s11427-014-4792-1. Epub 2014 Dec 20. PMID: 25528255.

4: Çınar Z, Edizer DT, Yiğit Ö, Altunay ZÖ, Gül M, Ataş A. Does Calcium Dobesilate Have Therapeutic Effect on Gentamicin-induced Cochlear Nerve Ototoxicity? An Experimental Study. Otol Neurotol. 2020 Dec;41(10):e1185-e1192. doi: 10.1097/MAO.0000000000002820. PMID: 32976341.

5: Guo X, Zhao F, Yin Y, Wang D, Hou L, Wu J, Li D, Cheng X, Xia L, Xu E, Qiu L. Calcium dobesilate: A drug treatment for diabetic retinopathy can negatively interfere with the measurement of glycated albumin using the enzymatic method. Clin Chim Acta. 2018 Aug;483:1-5. doi: 10.1016/j.cca.2018.04.014. Epub 2018 Apr 10. PMID: 29653084.

6: Ciapponi A, Laffaire E, Roqué M. Calcium dobesilate for chronic venous insufficiency: a systematic review. Angiology. 2004 Mar-Apr;55(2):147-54. doi: 10.1177/000331970405500206. PMID: 15026869.

7: Changazi SH, Bhatti S, Choudary A Sr, Rajput MNA, Iqbal Z, Ahmed QA. Calcium Dobesilate Versus Flavonoids for the Treatment of Early Hemorrhoidal Disease: A Randomized Controlled Trial. Cureus. 2020 Aug 18;12(8):e9845. doi: 10.7759/cureus.9845. PMID: 32953352; PMCID: PMC7497765.

8: Zhou Y, Qi C, Li S, Shao X, Ni Z. Investigation of the Mechanism Underlying Calcium Dobesilate-Mediated Improvement of Endothelial Dysfunction and Inflammation Caused by High Glucose. Mediators Inflamm. 2019 Oct 21;2019:9893682. doi: 10.1155/2019/9893682. PMID: 31780874; PMCID: PMC6855025.

9: Tejerina T, Ruiz E. Calcium dobesilate: pharmacology and future approaches. Gen Pharmacol. 1998 Sep;31(3):357-60. doi: 10.1016/s0306-3623(98)00040-8. PMID: 9703201.

10: Martinez-Zapata MJ, Vernooij RW, Uriona Tuma SM, Stein AT, Moreno RM, Vargas E, Capellà D, Bonfill Cosp X. Phlebotonics for venous insufficiency. Cochrane Database Syst Rev. 2016 Apr 6;4(4):CD003229. doi: 10.1002/14651858.CD003229.pub3. Update in: Cochrane Database Syst Rev. 2020 Nov 3;11:CD003229. PMID: 27048768; PMCID: PMC7173720.