7-Methoxyflavone
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MedKoo CAT#: 464267

CAS#: 22395-22-8

Description: 7-Methoxyflavone is a flavone that has been found in Z. brasiliensis and has diverse biological activities. It inhibits aromatase (IC50 = 1.9 µM in a cell-free assay) and LPS-induced nitric oxide (NO) production by 17.74% in RAW 264.7 macrophages when used at a concentration of 20 µM.1,2 7-Methoxyflavone activates androgen and/or glucocorticoid receptor transcriptional activity in a reporter assay and has antinociceptive effects in the acetic acid-induced writhing test in mice (ED50 = 82.5 µmol/kg).


Chemical Structure

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7-Methoxyflavone
CAS# 22395-22-8

Theoretical Analysis

MedKoo Cat#: 464267
Name: 7-Methoxyflavone
CAS#: 22395-22-8
Chemical Formula: C16H12O3
Exact Mass: 252.0786
Molecular Weight: 252.269
Elemental Analysis: C, 76.18; H, 4.79; O, 19.03

Price and Availability

Size Price Availability Quantity
1.0g USD 230.0 2 Weeks
5.0g USD 450.0 2 Weeks
10.0g USD 720.0 2 Weeks
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Synonym: 7-Methoxyflavone; 7 Methoxyflavone;

IUPAC/Chemical Name: 7-methoxy-2-phenyl-4H-chromen-4-one

InChi Key: QKNDCRMJDZLFEG-UHFFFAOYSA-N

InChi Code: InChI=1S/C16H12O3/c1-18-12-7-8-13-14(17)10-15(19-16(13)9-12)11-5-3-2-4-6-11/h2-10H,1H3

SMILES Code: O=C1C=C(OC2=CC(OC)=CC=C12)C3=CC=CC=C3

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 252.269 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Aksoy M, Öztekin A. Using of group-based selected flavonoids as alternative inhibitors for potato polyphenol oxidase. J Food Biochem. 2021 Mar 9:e13700. doi: 10.1111/jfbc.13700. Epub ahead of print. PMID: 33687091.

2: Qu Z, Chen Y, Luo ZH, Shen XL, Hu YJ. 7-methoxyflavanone alleviates neuroinflammation in lipopolysaccharide-stimulated microglial cells by inhibiting TLR4/MyD88/MAPK signalling and activating the Nrf2/NQO-1 pathway. J Pharm Pharmacol. 2020 Mar;72(3):385-395. doi: 10.1111/jphp.13219. Epub 2019 Dec 22. PMID: 31867739.

3: Yang W, Jo J, Oh H, Lee H, Chung WJ, Seo J. Peptoid Helix Displaying Flavone and Porphyrin: Synthesis and Intramolecular Energy Transfer. J Org Chem. 2020 Feb 7;85(3):1392-1400. doi: 10.1021/acs.joc.9b02358. Epub 2019 Nov 8. PMID: 31657570.