WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 464215
Description: XH04 is a novel selective estrogen receptor degrader (SERD), possessing significant antiestrogen and ERα property in MCF-7 cells.
MedKoo Cat#: 464215
Chemical Formula: C26H20O7
Exact Mass: 444.1209
Molecular Weight: 444.439
Elemental Analysis: C, 70.27; H, 4.54; O, 25.20
This product is not in stock, which may be available by custom synthesis.
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Synonym: XH04; XH 04; XH-04;
IUPAC/Chemical Name: (E)-3-(4-((7-hydroxy-3-(4-methoxybenzoyl)-2H-chromen-4-yl)oxy)phenyl)acrylic acid
InChi Key: LBWBHKUNBOWPJR-YIXHJXPBSA-N
InChi Code: InChI=1S/C26H20O7/c1-31-19-10-5-17(6-11-19)25(30)22-15-32-23-14-18(27)7-12-21(23)26(22)33-20-8-2-16(3-9-20)4-13-24(28)29/h2-14,27H,15H2,1H3,(H,28,29)/b13-4+
SMILES Code: O=C(O)/C=C/C1=CC=C(OC2=C(C(C3=CC=C(OC)C=C3)=O)COC4=C2C=CC(O)=C4)C=C1
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: to be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 444.439 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Lu X, Teng Y, Lin X, Xiao M, Liu C, Chi X, Zhang Y, Luo G, Xiang H. Discovery of novel 2H-chromene-3-carbonyl derivatives as selective estrogen receptor degraders (SERDs): Design, synthesis and biological evaluation. Bioorg Chem. 2021 Feb 9;109:104714. doi: 10.1016/j.bioorg.2021.104714. Epub ahead of print. PMID: 33618254.