M-5717
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MedKoo CAT#: 413494

CAS#: 1469439-69-7

Description: M-5717 is an antimalarial drug candidate


Chemical Structure

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M-5717
CAS# 1469439-69-7

Theoretical Analysis

MedKoo Cat#: 413494
Name: M-5717
CAS#: 1469439-69-7
Chemical Formula: C27H31FN4O2
Exact Mass: 462.2431
Molecular Weight: 462.57
Elemental Analysis: C, 70.11; H, 6.76; F, 4.11; N, 12.11; O, 6.92

Price and Availability

Size Price Availability Quantity
1.0mg USD 273.5 2 Weeks
5.0mg USD 562.8 2 Weeks
10.0mg USD 868.0 2 Weeks
25.0mg USD 1543.2 2 Weeks
Bulk inquiry

Synonym: M-5717; M5717; M 5717; DDD107498

IUPAC/Chemical Name: 6-Fluoro-2-(4-(4-morpholinylmethyl)phenyl)-N-(2-(1-pyrrolidinyl)ethyl)-4-quinolinecarboxamide

InChi Key: BENUHBSJOJMZEE-UHFFFAOYSA-N

InChi Code: InChI=1S/C27H31FN4O2/c28-22-7-8-25-23(17-22)24(27(33)29-9-12-31-10-1-2-11-31)18-26(30-25)21-5-3-20(4-6-21)19-32-13-15-34-16-14-32/h3-8,17-18H,1-2,9-16,19H2,(H,29,33)

SMILES Code: O=C(C1=CC(C2=CC=C(CN3CCOCC3)C=C2)=NC4=CC=C(F)C=C14)NCCN5CCCC5

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: to be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 462.57 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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Reconstitution Calculator

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1: Rottmann M, Jonat B, Gumpp C, Dhingra SK, Giddins MJ, Yin X, Badolo L, Greco B, Fidock DA, Oeuvray C, Spangenberg T. Preclinical Antimalarial Combination Study of M5717, a Plasmodium falciparum Elongation Factor 2 Inhibitor, and Pyronaridine, a Hemozoin Formation Inhibitor. Antimicrob Agents Chemother. 2020 Mar 24;64(4):e02181-19. doi: 10.1128/AAC.02181-19. PMID: 32041711; PMCID: PMC7179297.

2: Arez F, Rebelo SP, Fontinha D, Simão D, Martins TR, Machado M, Fischli C, Oeuvray C, Badolo L, Carrondo MJT, Rottmann M, Spangenberg T, Brito C, Greco B, Prudêncio M, Alves PM. Flexible 3D Cell-Based Platforms for the Discovery and Profiling of Novel Drugs Targeting Plasmodium Hepatic Infection. ACS Infect Dis. 2019 Nov 8;5(11):1831-1842. doi: 10.1021/acsinfecdis.9b00144. Epub 2019 Sep 13. PMID: 31479238.

M-5717

1.0mg / USD 273.5