WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 464200
Description: O-Carbamate 66 is a novel potent antileishmanial and antitrypanosomal agent, offering a more optimal balance of increased solubility, suitable metabolic stability, excellent oral bioavailability (100%), and strong in vivo efficacy in a visceral leishmaniasis mouse model (97% parasite load reduction at 25 mg/kg).
MedKoo Cat#: 464200
Name: O-Carbamate 66
Chemical Formula: C16H15F3N4O6
Exact Mass: 416.0944
Molecular Weight: 416.3132
Elemental Analysis: C, 46.16; H, 3.63; F, 13.69; N, 13.46; O, 23.06
This product is not in stock, which may be available by custom synthesis.
For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge).
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Synonym: O-Carbamate 66; O-Carbamate-66; O Carbamate 66; O Carbamate-66;
IUPAC/Chemical Name: (7-methyl-2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazin-7-yl)methyl (4-(trifluoromethoxy)phenyl)carbamate
InChi Key: HBJBNGLJCUFYIO-UHFFFAOYSA-N
InChi Code: InChI=1S/C16H15F3N4O6/c1-15(6-7-22-8-12(23(25)26)21-13(22)29-15)9-27-14(24)20-10-2-4-11(5-3-10)28-16(17,18)19/h2-5,8H,6-7,9H2,1H3,(H,20,24)
SMILES Code: O=C(OCC1(C)CCN2C(O1)=NC([N+]([O-])=O)=C2)NC3=CC=C(OC(F)(F)F)C=C3
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: to be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 416.3132 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Thompson AM, O'Connor PD, Yardley V, Maes L, Launay D, Braillard S, Chatelain E, Wan B, Franzblau SG, Ma Z, Cooper CB, Denny WA. Novel Linker Variants of Antileishmanial/Antitubercular 7-Substituted 2-Nitroimidazooxazines Offer Enhanced Solubility. ACS Med Chem Lett. 2021 Jan 21;12(2):275-281. doi: 10.1021/acsmedchemlett.0c00649. PMID: 33603975; PMCID: PMC7883471.