WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 464199
Description: YQ456 is a novel potent and selective inhibitor of myoferlin (MYOF inhibitor), which attenuates colorectal cancer progression. YQ456 showed high binding affinity to MYOF (KD = 37 nM) and excellent anti-invasion capability (IC50 = 110 nM). YQ456 was reported for the first time to interfere with the interactions between MYOF and Ras-associated binding (Rab) proteins at low nanomolar levels. This interference disrupted several vesicle trafficking processes, including lysosomal degradation, exosome secretion, and mitochondrial dynamics. Further, YQ456 exhibited excellent inhibitory effects on the growth and invasiveness of colorectal cancer. As the first attempt, the anticancer efficacy of YQ456 in the patient-derived xenograft (PDX) mouse model indicated that targeting MYOF may serve as a novel and practical therapeutic approach for colorectal cancer.
MedKoo Cat#: 464199
Chemical Formula: C28H30N4O2
Exact Mass: 454.2369
Molecular Weight: 454.574
Elemental Analysis: C, 73.98; H, 6.65; N, 12.33; O, 7.04
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Synonym: YQ456; YQ 456; YQ-456;
IUPAC/Chemical Name: 3-(3-ethyl-5-(4-methoxyphenyl)-1H-1,2,4-triazol-1-yl)-N-(4-phenylbutyl)benzamide
InChi Key: MSZAOWHKERXHJX-UHFFFAOYSA-N
InChi Code: InChI=1S/C28H30N4O2/c1-3-26-30-27(22-15-17-25(34-2)18-16-22)32(31-26)24-14-9-13-23(20-24)28(33)29-19-8-7-12-21-10-5-4-6-11-21/h4-6,9-11,13-18,20H,3,7-8,12,19H2,1-2H3,(H,29,33)
SMILES Code: O=C(NCCCCC1=CC=CC=C1)C2=CC=CC(N3N=C(CC)N=C3C4=CC=C(OC)C=C4)=C2
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: to be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 454.574 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: He Y, Kan W, Li Y, Hao Y, Huang A, Gu H, Wang M, Wang Q, Chen J, Sun Z, Liu M, Chen Y, Yi Z. A potent and selective small molecule inhibitor of myoferlin attenuates colorectal cancer progression. Clin Transl Med. 2021 Feb;11(2):e289. doi: 10.1002/ctm2.289. PMID: 33634965; PMCID: PMC7868085.