DAU 5884 HCl
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MedKoo CAT#: 413485

CAS#: 131780-47-7

Description: DAU 5884 HCl is an M3 receptor antagonist


Chemical Structure

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DAU 5884 HCl
CAS# 131780-47-7

Theoretical Analysis

MedKoo Cat#: 413485
Name: DAU 5884 HCl
CAS#: 131780-47-7
Chemical Formula: C17H22ClN3O3
Exact Mass: 0.00
Molecular Weight: 351.830
Elemental Analysis: C, 58.04; H, 6.30; Cl, 10.08; N, 11.94; O, 13.64

Price and Availability

Size Price Availability Quantity
10mg USD 345 2 Weeks
50mg USD 983 2 Weeks
Bulk inquiry

Synonym: DAU 5884 hydrochloride; DAU 5884 HCl; DAU5884; DAU5884; DAU5884

IUPAC/Chemical Name: (1R,5S)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl 2-oxo-1,4-dihydroquinazoline-3(2H)-carboxylate hydrochloride

InChi Key: FDERDDSQHZRNGC-LIWIJTDLSA-N

InChi Code: InChI=1S/C17H21N3O3.ClH/c1-19-12-6-7-13(19)9-14(8-12)23-17(22)20-10-11-4-2-3-5-15(11)18-16(20)21;/h2-5,12-14H,6-10H2,1H3,(H,18,21);1H/t12-,13+,14?;

SMILES Code: CN1[C@@H]2CC[C@H]1CC(OC(N3Cc4c(NC3=O)cccc4)=O)C2.Cl

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: to be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
To be determined 0.0 100.00

Preparing Stock Solutions

The following data is based on the product molecular weight 351.83 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Drumm BT, Rembetski BE, Huynh K, Nizar A, Baker SA, Sanders KM. Excitatory cholinergic responses in mouse colon intramuscular interstitial cells of Cajal are due to enhanced Ca2+ release via M3 receptor activation. FASEB J. 2020 Aug;34(8):10073-10095. doi: 10.1096/fj.202000672R. Epub 2020 Jun 15. PMID: 32539213; PMCID: PMC7790594.

2: Nieto JE, Morales B, Yamout SZ, Stanley SD, Harmon FA, Snyder JR. In vivo and in vitro effects of neostigmine on gastrointestinal tract motility of horses. Am J Vet Res. 2013 Apr;74(4):579-88. doi: 10.2460/ajvr.74.4.579. PMID: 23531066.

3: Doods HN, Willim KD, Boddeke HW, Entzeroth M. Characterization of muscarinic receptors in guinea-pig uterus. Eur J Pharmacol. 1993 Dec 7;250(2):223-30. doi: 10.1016/0014-2999(93)90385-u. PMID: 8112383.

4: Myslivecek J, Klein M, Novakova M, Ricny J. The detection of the non-M2 muscarinic receptor subtype in the rat heart atria and ventricles. Naunyn Schmiedebergs Arch Pharmacol. 2008 Jul;378(1):103-16. doi: 10.1007/s00210-008-0285-8. Epub 2008 Apr 29. PMID: 18443764.

5: Rinaldo L, Hansel C. Muscarinic acetylcholine receptor activation blocks long-term potentiation at cerebellar parallel fiber-Purkinje cell synapses via cannabinoid signaling. Proc Natl Acad Sci U S A. 2013 Jul 2;110(27):11181-6. doi: 10.1073/pnas.1221803110. Epub 2013 Jun 17. PMID: 23776234; PMCID: PMC3704018.

6: Guo Q, Jiang YJ, Jin H, Jiang XH, Gu B, Zhang YM, Wang JG, Qin ZH, Tao J. Modulation of A-type K+ channels by the short-chain cobrotoxin through the protein kinase C-delta isoform decreases membrane excitability in dorsal root ganglion neurons. Biochem Pharmacol. 2013 May 1;85(9):1352-62. doi: 10.1016/j.bcp.2013.02.019. Epub 2013 Feb 19. Erratum in: Biochem Pharmacol. 2013 Nov 15;86(10):1515. PMID: 23435353.

7: Gosens R, Bromhaar MM, Tonkes A, Schaafsma D, Zaagsma J, Nelemans SA, Meurs H. Muscarinic M(3) receptor-dependent regulation of airway smooth muscle contractile phenotype. Br J Pharmacol. 2004 Mar;141(6):943-50. doi: 10.1038/sj.bjp.0705709. Epub 2004 Mar 1. PMID: 14993104; PMCID: PMC1574278.

8: Wuest M, Eichhorn B, Braeter M, Strugala G, Michel MC, Ravens U. Muscarinic receptor expression and receptor-mediated detrusor contraction: comparison of juvenile and adult porcine tissue. Pflugers Arch. 2008 May;456(2):349-58. doi: 10.1007/s00424-007-0407-z. Epub 2007 Dec 21. PMID: 18157728.

9: Gosens R, Nelemans SA, Grootte Bromhaar MM, McKay S, Zaagsma J, Meurs H. Muscarinic M3-receptors mediate cholinergic synergism of mitogenesis in airway smooth muscle. Am J Respir Cell Mol Biol. 2003 Feb;28(2):257-62. doi: 10.1165/rcmb.2002-0128OC. PMID: 12540494.

10: Roffel AF, Elzinga CR, Zaagsma J. Cholinergic contraction of the guinea pig lung strip is mediated by muscarinic M2-like receptors. Eur J Pharmacol. 1993 Dec 7;250(2):267-79. doi: 10.1016/0014-2999(93)90391-t. PMID: 8112384.