Daunorubicin hydrochloride
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MedKoo CAT#: 100240

CAS#: 23541-50-6 (HCl)

Description: Daunorubicin hydrochloride is the hydrochloride salt of an anthracycline antineoplastic antibiotic with therapeutic effects similar to those of doxorubicin. Daunorubicin exhibits cytotoxic activity through topoisomerase-mediated interaction with DNA, thereby inhibiting DNA replication and repair and RNA and protein synthesis.


Chemical Structure

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Daunorubicin hydrochloride
CAS# 23541-50-6 (HCl)

Theoretical Analysis

MedKoo Cat#: 100240
Name: Daunorubicin hydrochloride
CAS#: 23541-50-6 (HCl)
Chemical Formula: C27H30ClNO10
Exact Mass:
Molecular Weight: 563.98
Elemental Analysis: C, 57.50; H, 5.36; Cl, 6.29; N, 2.48; O, 28.37

Size Price Shipping out time Quantity
100mg USD 150 Same day
200mg USD 250 Same day
500mg USD 450 Same day
1g USD 750 Same day
2g USD 1150 Same day
5g USD 1850 Same day
10g USD 2650 Same day
20g USD 4250 Same day
Inquire bulk and customized quantity

Pricing updated 2021-03-06. Prices are subject to change without notice.

Daunorubicin hydrochloride, purity > 98%, is in stock. The same day shipping out after order is received.

Related CAS #: 23541-50-6 (HCl)   20830-81-3 (free base)    

Synonym: Daunomycin hydrochloride; daunomycin HCl; daunorubidomycine; US brand names: Cerubidine; Rubidomycin; Foreign brand names: Cerubidin; Daunoblastin; Daunoblastina; Ondena; Rubilem; Abbreviations: DNM; DNR; DRB; Code names: FI6339; RP13057.

IUPAC/Chemical Name: (8S,10S)-8-acetyl-10-(((2S,4S,5S,6S)-4-amino-5-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-6,8,11-trihydroxy-1-methoxy-7,8,9,10-tetrahydrotetracene-5,12-dione hydrochloride.

InChi Key: GUGHGUXZJWAIAS-VGUYFWKPSA-N

InChi Code: InChI=1S/C27H29NO10.ClH/c1-10-22(30)14(28)7-17(37-10)38-16-9-27(35,11(2)29)8-13-19(16)26(34)21-20(24(13)32)23(31)12-5-4-6-15(36-3)18(12)25(21)33;/h4-6,10,14,16-17,22,30,32,34-35H,7-9,28H2,1-3H3;1H/t10-,14-,16-,17+,22+,27-;/m0./s1

SMILES Code: O=C1C2=C(O)C(C[C@@](O)(C(C)=O)C[C@@H]3O[C@H]4O[C@@H](C)[C@@H](O)[C@@H](N)C4)=C3C(O)=C2C(C5=C1C=CC=C5OC)=O.[H]Cl

Appearance:
Red solid powder

Purity:
>99% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 563.98 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Nikolskaya E, Sokol M, Faustova M, Zhunina O, Mollaev M, Yabbarov N, Tereshchenko O, Popov R, Severin E. The comparative study of influence of lactic and glycolic acids copolymers type on properties of daunorubicin loaded nanoparticles and drug release. Acta Bioeng Biomech. 2018;20(1):65-77. PubMed PMID: 29658530.

2: Uematsu N, Zhao Y, Kiyomi A, Yuan BO, Onda K, Tanaka S, Sugiyama K, Sugiura M, Takagi N, Hayakawa A, Hirano T. Chemo-sensitivity of Two-dimensional Monolayer and Three-dimensional Spheroid of Breast Cancer MCF-7 Cells to Daunorubicin, Docetaxel, and Arsenic Disulfide. Anticancer Res. 2018 Apr;38(4):2101-2108. PubMed PMID: 29599328.

3: Chakraborty M, Sellier C, Ney M, Villa P, Charlet-Berguerand N, Artero R, Llamusi B. Daunorubicin reduces MBNL1 titration by expanded CUG repeat RNA and rescues cardiac dysfunctions in a Drosophila model of myotonic dystrophy. Dis Model Mech. 2018 Mar 21. pii: dmm.032557. doi: 10.1242/dmm.032557. [Epub ahead of print] PubMed PMID: 29592894.

4: Seddon AN, Chaim J, Akin O, Drill E, Michael AG, Adel N, Tallman MS. Similar incidence of typhlitis in patients receiving various doses of daunorubicin or idarubicin as induction for acute myeloid leukemia. Leuk Res. 2018 May;68:48-50. doi: 10.1016/j.leukres.2018.03.004. Epub 2018 Mar 8. PubMed PMID: 29544131.

5: Kim M, Williams S. Daunorubicin and Cytarabine Liposome in Newly Diagnosed Therapy-Related Acute Myeloid Leukemia (AML) or AML With Myelodysplasia-Related Changes. Ann Pharmacother. 2018 Mar 1:1060028018764923. doi: 10.1177/1060028018764923. [Epub ahead of print] PubMed PMID: 29532662.

6: Cao J, Zheng H, Hu R, Liao J, Fei Z, Wei X, Xiong X, Zhang F, Zheng H, Li D. pH-Responsive Nanoparticles Based on Covalently Grafted Conjugates of Carboxymethyl Chitosan and Daunorubicin for the Delivery of Anti-Cancer Drugs. J Biomed Nanotechnol. 2017 Dec 1;13(12):1647-1659. doi: 10.1166/jbn.2017.2462. PubMed PMID: 29490753.

7: Ju RJ, Cheng L, Peng XM, Wang T, Li CQ, Song XL, Liu S, Chao JP, Li XT. Octreotide-modified liposomes containing daunorubicin and dihydroartemisinin for treatment of invasive breast cancer. Artif Cells Nanomed Biotechnol. 2018 Jan 30:1-13. doi: 10.1080/21691401.2018.1433187. [Epub ahead of print] PubMed PMID: 29381101.

8: Ju RJ, Cheng L, Qiu X, Liu S, Song XL, Peng XM, Wang T, Li CQ, Li XT. Hyaluronic acid modified daunorubicin plus honokiol cationic liposomes for the treatment of breast cancer along with the elimination vasculogenic mimicry channels. J Drug Target. 2018 Jan 24:1-13. doi: 10.1080/1061186X.2018.1428809. [Epub ahead of print] PubMed PMID: 29334266.

9: Kim SY, Park JH, Yoon SY, Cho YH, Lee MH. A pilot study of daunorubicin-augmented hyper-CVAD induction chemotherapy for adults with acute lymphoblastic leukemia. Cancer Chemother Pharmacol. 2018 Feb;81(2):393-398. doi: 10.1007/s00280-017-3514-3. Epub 2018 Jan 2. PubMed PMID: 29294168.

10: Maayah ZH, Abdelhamid G, Elshenawy OH, El-Sherbeni AA, Althurwi HN, McGinn E, Dawood D, Alammari AH, El-Kadi AOS. The Role of Soluble Epoxide Hydrolase Enzyme on Daunorubicin-Mediated Cardiotoxicity. Cardiovasc Toxicol. 2017 Dec 1. doi: 10.1007/s12012-017-9437-8. [Epub ahead of print] PubMed PMID: 29196978.

11: Nikanjam M, Capparelli EV, Lancet JE, Louie A, Schiller G. Persistent cytarabine and daunorubicin exposure after administration of novel liposomal formulation CPX-351: population pharmacokinetic assessment. Cancer Chemother Pharmacol. 2018 Jan;81(1):171-178. doi: 10.1007/s00280-017-3484-5. Epub 2017 Nov 22. PubMed PMID: 29167924; PubMed Central PMCID: PMC5756117.

12: Shi ZX, Li HY, Yang XD, Gao H, Li DG, Yang WH, Yao F, Yan LX. Yi-qi-yang-yin-tang increases the sensitivity of KG1a leukemia stem cells to daunorubicin by promoting cell cycle progression and regulating the expression of PTEN, TOPOII and mTOR. Oncol Lett. 2017 Dec;14(6):6441-6448. doi: 10.3892/ol.2017.7067. Epub 2017 Sep 26. PubMed PMID: 29163680; PubMed Central PMCID: PMC5686439.

13: Jackson DR, Shakya G, Patel AB, Mohammed LY, Vasilakis K, Wattana-Amorn P, Valentic TR, Milligan JC, Crump MP, Crosby J, Tsai SC. Structural and Functional Studies of the Daunorubicin Priming Ketosynthase DpsC. ACS Chem Biol. 2018 Jan 19;13(1):141-151. doi: 10.1021/acschembio.7b00551. Epub 2017 Dec 11. PubMed PMID: 29161022.

14: Sheng X, Parmentier JH, Tucci J, Pei H, Cortez-Toledo O, Dieli-Conwright CM, Oberley MJ, Neely M, Orgel E, Louie SG, Mittelman SD. Adipocytes Sequester and Metabolize the Chemotherapeutic Daunorubicin. Mol Cancer Res. 2017 Dec;15(12):1704-1713. doi: 10.1158/1541-7786.MCR-17-0338. Epub 2017 Nov 8. PubMed PMID: 29117945; PubMed Central PMCID: PMC5726435.

15: Hu C, Yu M, Ren Y, Li K, Maggio DM, Mei C, Ye L, Wei J, Jin J, Zhuang Z, Tong H. Publisher Correction: PP2A inhibition from LB100 therapy enhances daunorubicin cytotoxicity in secondary acute myeloid leukemia via miR-181b-1 upregulation. Sci Rep. 2017 Nov 7;7(1):15260. doi: 10.1038/s41598-017-14858-z. PubMed PMID: 29116110; PubMed Central PMCID: PMC5677121.

16: Jiang HN, Liu ZG, Hu R. [Embelin Reverses the Multi-drug Resistance of K562/D to Daunorubicin Independently of P-gp and MDR1 mRNA]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2017 Oct;25(5):1342-1349. doi: 10.7534/j.issn.1009-2137.2017.05.011. Chinese. PubMed PMID: 29070105.

17: Li W, Lu M, Zhang Y, Xia D, Chen Z, Wang L, Yin N, Wang Z. Puerarin attenuates the daunorubicin-induced apoptosis of H9c2 cells by activating the PI3K/Akt signaling pathway via the inhibition of Ca2+ influx. Int J Mol Med. 2017 Dec;40(6):1889-1894. doi: 10.3892/ijmm.2017.3186. Epub 2017 Oct 12. PubMed PMID: 29039532.

18: Zhu K, Jiang B, Yang Y, Hu R, Liu Z. DACT1 overexpression inhibits proliferation, enhances apoptosis, and increases daunorubicin chemosensitivity in KG-1α cells. Tumour Biol. 2017 Oct;39(10):1010428317711089. doi: 10.1177/1010428317711089. PubMed PMID: 29037126.

19: Alves AC, Nunes C, Lima J, Reis S. Daunorubicin and doxorubicin molecular interplay with 2D membrane models. Colloids Surf B Biointerfaces. 2017 Dec 1;160:610-618. doi: 10.1016/j.colsurfb.2017.09.058. Epub 2017 Oct 3. PubMed PMID: 29028609.

20: Murphy T, Yee KWL. Cytarabine and daunorubicin for the treatment of acute myeloid leukemia. Expert Opin Pharmacother. 2017 Nov;18(16):1765-1780. doi: 10.1080/14656566.2017.1391216. Epub 2017 Oct 20. Review. PubMed PMID: 29017371.



Additional Information

 Related CAS#
23541-50-6 (Daunorubicin HCl);
20830-81-3 (Daunorubicin free base).