Cyclodisone

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 413413

CAS#: 99591-73-8

Description: Cyclodisone is a cyclic sulfonate ester with potential antineoplastic activity

Chemical Structure

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Cyclodisone
CAS# 99591-73-8
Instruction

Theoretical Analysis

MedKoo Cat#: 413413
Name: Cyclodisone
CAS#: 99591-73-8
Chemical Formula: C3H6O6S2
Exact Mass: 201.96
Molecular Weight: 202.190
Elemental Analysis: C, 17.82; H, 2.99; O, 47.48; S, 31.71

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: Cyclodisone; NSC348948; NSC348948; NSC-348948

IUPAC/Chemical Name: 1,5,2,4-Dioxadithiepane, 2,2,4,4-tetraoxide

InChi Key: RYIRMSRYCSMGJA-UHFFFAOYSA-N

InChi Code: InChI=1S/C3H6O6S2/c4-10(5)3-11(6,7)9-2-1-8-10/h1-3H2

SMILES Code: O=S(OCCOS1(=O)=O)(C1)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
Soluble in DMSO 0.0 100.00

Preparing Stock Solutions

The following data is based on the product molecular weight 202.19 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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Reconstitution Calculator

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Dilution Calculator

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1: Berardini MD, Pacheco DY, Gibson NW. Structure activity analysis of the formation of DNA damage induced in human tumor cells by the cyclodisone class of anti-tumor agent. Anticancer Drug Des. 1991 May;6(2):119-27. PMID: 2039582.

2: Gibson NW. Comparison of the in vitro cytotoxicity of cyclodisone with a series of structurally related analogues. Anticancer Drug Des. 1988 Dec;3(3):199-204. PMID: 3272138.

3: Gibson NW. Characterization of DNA damage and cytotoxicity induced in two human colon carcinoma cell lines by cyclodisone. Cancer Res. 1989 Jan 1;49(1):154-7. PMID: 2908842.

4: Dive C, Workman P, Watson JV. Inhibition of cellular esterases by the antitumour imidazotetrazines mitozolomide and temozolomide: demonstration by flow cytometry and conventional spectrofluorimetry. Cancer Chemother Pharmacol. 1989;25(3):149-55. doi: 10.1007/BF00689574. PMID: 2557170.

5: Umprayn K, Kennedy PE, Lee JC, Waugh W, Riley CM, Stella VJ. Development of reversed-phase HPLC assays for cyclodisone and clomesone. J Pharm Biomed Anal. 1987;5(6):625-33. doi: 10.1016/0731-7085(87)80075-4. PMID: 16867487.

6: Gibson NW, Hartley JA, Kohn KW. DNA reactivity and in vitro cytotoxicity of the novel antitumor agent 1,5,2,4-dioxadithiepane-2,2,4,4-tetraoxide (NSC-348948) in human embryo cells. Cancer Res. 1986 Apr;46(4 Pt 1):1679-83. PMID: 3509975.