Vilanterol
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 576084

CAS#: 503068-34-6

Description: Vilanterol is an ultra-long acting β2-adrenoceptor agonist (ultra-LABA).


Chemical Structure

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Vilanterol
CAS# 503068-34-6

Theoretical Analysis

MedKoo Cat#: 576084
Name: Vilanterol
CAS#: 503068-34-6
Chemical Formula: C24H33Cl2NO5
Exact Mass: 485.1736
Molecular Weight: 486.43
Elemental Analysis: C, 59.26; H, 6.84; Cl, 14.58; N, 2.88; O, 16.45

Price and Availability

Size Price Availability Quantity
1.0mg USD 235.0 2 Weeks
5.0mg USD 670.0 2 Weeks
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Synonym: GW 642444; GW642444; GW-642444; Vilanterol

IUPAC/Chemical Name: (R)-4-(2-((6-(2-((2,6-dichlorobenzyl)oxy)ethoxy)hexyl)amino)-1-hydroxyethyl)-2-(hydroxymethyl)phenol

InChi Key: DAFYYTQWSAWIGS-DEOSSOPVSA-N

InChi Code: InChI=1S/C24H33Cl2NO5/c25-21-6-5-7-22(26)20(21)17-32-13-12-31-11-4-2-1-3-10-27-15-24(30)18-8-9-23(29)19(14-18)16-28/h5-9,14,24,27-30H,1-4,10-13,15-17H2/t24-/m0/s1

SMILES Code: ClC1=C(COCCOCCCCCCNC[C@H](O)C2=CC=C(O)C(CO)=C2)C(Cl)=CC=C1

Appearance: A solution in ethanol

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, DMF, Ethanol

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 486.43 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1. Cazzola, M., Calzetta, L., and Matera, M.G. β2-adrenoceptor agonists: Current and future direction. Br. J. Pharmacol. 163(1), 4-17 (2011).

2. Mach, R.H., Nader, M.A., Ehrenkaufer, R.L., et al. Comparison of two fluorine-18 labeled benzamide derivatives that bind reversibly to dopamine D2 receptors: In vitro binding studies and positron emission tomography. Synapse 24(4), 322-333 (1996).

3. Procopiou, P.A., Barrett, V.J., Bevan, N.J., et al. Synthesis and structure-activity relationships of long-acting beta2 adrenergic receptor agonists incorporating metabolic inactivation: An antedrug approach. J. Med. Chem. 53(11), 4522-4530 (2010).

4. De Coster, D.A., and Jones, M. Tailoring of corticosteroids in COPD management. Curr.Respir.Care Rep. 3, 121-132 (2014).

5. Cohen, J.S., Miles, M.C., Donohue, J.F., et al. Dual therapy strategies for COPD: The scientific rationale for LAMA + LABA. Int. J. Chron. Obstruct. Pulmon. Dis. 11, 785-797 (2016).