WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 464101
Description: ZINC40099027 is FAK activator. ZINC40099027 promotes FAK phosphorylation, inducing mucosal healing in murine models.
MedKoo Cat#: 464101
Chemical Formula: C23H26F3N3O3
Exact Mass: 449.1926
Molecular Weight: 449.4742
Elemental Analysis: C, 61.46; H, 5.83; F, 12.68; N, 9.35; O, 10.68
Synonym: ZINC40099027; ZINC 40099027; ZINC-40099027;
IUPAC/Chemical Name: 2-(4-methoxyphenyl)-N-(2-morpholino-5-(trifluoromethyl)phenyl)pyrrolidine-1-carboxamide
InChi Key: MOEURIVQRFKTCR-UHFFFAOYSA-N
InChi Code: InChI=1S/C23H26F3N3O3/c1-31-18-7-4-16(5-8-18)20-3-2-10-29(20)22(30)27-19-15-17(23(24,25)26)6-9-21(19)28-11-13-32-14-12-28/h4-9,15,20H,2-3,10-14H2,1H3,(H,27,30)
SMILES Code: O=C(N1C(C2=CC=C(OC)C=C2)CCC1)NC3=CC(C(F)(F)F)=CC=C3N4CCOCC4
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 449.4742 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Wang Q, More SK, Vomhof-DeKrey EE, Golovko MY, Basson MD. Small molecule FAK activator promotes human intestinal epithelial monolayer wound closure and mouse ulcer healing. Sci Rep. 2019 Oct 11;9(1):14669. doi: 10.1038/s41598-019-51183-z. PMID: 31604999; PMCID: PMC6789032.