Icopezil

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 413312

CAS#: 145508-78-7 (free base)

Description: Icopezil was developed as a selective acetylcholinesterase inhibitor for the treatment of cognitive disorders.


Chemical Structure

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Icopezil
CAS# 145508-78-7 (free base)

Theoretical Analysis

MedKoo Cat#: 413312
Name: Icopezil
CAS#: 145508-78-7 (free base)
Chemical Formula: C23H25N3O2
Exact Mass: 375.1947
Molecular Weight: 375.47
Elemental Analysis: C, 73.57; H, 6.71; N, 11.19; O, 8.52

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Related CAS #: 145815-98-1 (maleate)   145508-78-7 (free base)  

Synonym: Icopezil; CP118954; CP-118954; CP 118954

IUPAC/Chemical Name: 3-(2-(1-benzylpiperidin-4-yl)ethyl)-5,7-dihydro-6H-isoxazolo[4,5-f]indol-6-one

InChi Key: MTCMTKNMZCPKLX-UHFFFAOYSA-N

InChi Code: InChI=1S/C23H25N3O2/c27-23-13-18-12-19-20(25-28-22(19)14-21(18)24-23)7-6-16-8-10-26(11-9-16)15-17-4-2-1-3-5-17/h1-5,12,14,16H,6-11,13,15H2,(H,24,27)

SMILES Code: O=C1Cc(c2)c(N1)cc3c2c(CCC4CCN(CC4)Cc5ccccc5)no3

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 375.47 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Liston DR, Nielsen JA, Villalobos A, Chapin D, Jones SB, Hubbard ST, Shalaby IA, Ramirez A, Nason D, White WF. Pharmacology of selective acetylcholinesterase inhibitors: implications for use in Alzheimer's disease. Eur J Pharmacol. 2004 Feb 13;486(1):9-17. doi: 10.1016/j.ejphar.2003.11.080. PMID: 14751402.