p53 Reactivator C85

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 464049

CAS#: unknown

Description: p53 Reactivator C85 is a novel reactivator of mutant p53, functioning as a zinc metallochaperone (ZMC) with diminished copper binding that functions as a chemotherapy and radiation sensitizer.


Chemical Structure

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p53 Reactivator C85
CAS# unknown

Theoretical Analysis

MedKoo Cat#: 464049
Name: p53 Reactivator C85
CAS#: unknown
Chemical Formula: C20H22F2N6
Exact Mass: 384.19
Molecular Weight: 384.435
Elemental Analysis: C, 62.49; H, 5.77; F, 9.88; N, 21.86

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: p53 Reactivator C85; p53-Reactivator-C85;

IUPAC/Chemical Name: (E)-1-(2-(3,3-difluoropyrrolidin-1-yl)ethyl)-2-(2-(1-(pyridin-2-yl)ethylidene)hydrazinyl)-1H-benzo[d]imidazole

InChi Key: VGIXWWLJCGSRBH-MFKUBSTISA-N

InChi Code: InChI=1S/C20H22F2N6/c1-15(16-6-4-5-10-23-16)25-26-19-24-17-7-2-3-8-18(17)28(19)13-12-27-11-9-20(21,22)14-27/h2-8,10H,9,11-14H2,1H3,(H,24,26)/b25-15+

SMILES Code: C/C(C1=NC=CC=C1)=N\NC2=NC3=CC=CC=C3N2CCN4CC(F)(F)CC4

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
Soluble in DMSO 0.0 100.00

Preparing Stock Solutions

The following data is based on the product molecular weight 384.43 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Gilleran JA, Yu X, Blayney AJ, Bencivenga AF, Na B, Augeri DJ, Blanden AR, Kimball SD, Loh SN, Roberge JY, Carpizo DR. Benzothiazolyl and Benzoxazolyl Hydrazones Function as Zinc Metallochaperones to Reactivate Mutant p53. J Med Chem. 2021 Feb 4. doi: 10.1021/acs.jmedchem.0c01360. Epub ahead of print. PMID: 33538587.