WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 413296
Description: Yohimbine is a plant alkaloid with alpha-2-adrenergic blocking activity. Yohimbine has been used as a mydriatic and in the treatment of ERECTILE DYSFUNCTION.
MedKoo Cat#: 413296
Chemical Formula: C21H26N2O3
Exact Mass: 354.1943
Molecular Weight: 354.45
Elemental Analysis: C, 71.16; H, 7.39; N, 7.90; O, 13.54
This product is not in stock, which may be available by custom synthesis.
For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge).
Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.
Synonym: Yohimbine; CCRIS9415; CCRIS-9415; CCRIS 9415
IUPAC/Chemical Name: methyl (1R,2S,4aR,13bS,14aS)-2-hydroxy-1,2,3,4,4a,5,7,8,13,13b,14,14a-dodecahydroindolo[2',3':3,4]pyrido[1,2-b]isoquinoline-1-carboxylate
InChi Key: BLGXFZZNTVWLAY-SCYLSFHTSA-N
InChi Code: InChI=1S/C21H26N2O3/c1-26-21(25)19-15-10-17-20-14(13-4-2-3-5-16(13)22-20)8-9-23(17)11-12(15)6-7-18(19)24/h2-5,12,15,17-19,22,24H,6-11H2,1H3/t12-,15-,17-,18-,19+/m0/s1
SMILES Code: COC([C@H]1[C@H](CC[C@H]2CN3CCc(c([C@@H]3C[C@H]12)[nH]4)c5c4cccc5)O)=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 354.45 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
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2: Cimolai N, Cimolai T. Yohimbine use for physical enhancement and its potential toxicity. J Diet Suppl. 2011 Dec;8(4):346-54. doi: 10.3109/19390211.2011.615806. Epub 2011 Oct 21. PMID: 22432773.
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6: Vay M, Sauter M, Mikus G, Burhenne J. Quantification of microdosed oral yohimbine and its major metabolite in human plasma in the picogram range. Bioanalysis. 2019 Aug;11(16):1459-1467. doi: 10.4155/bio-2019-0129. Epub 2019 Aug 14. PMID: 31411489.
7: Riley AJ. Yohimbine in the treatment of erectile disorder. Br J Clin Pract. 1994 May-Jun;48(3):133-6. PMID: 8031688.
8: Morales A. Yohimbine in erectile dysfunction: the facts. Int J Impot Res. 2000 Mar;12 Suppl 1:S70-74. PMID: 10845767.
9: Morales A. Yohimbine in erectile dysfunction: would an orphan drug ever be properly assessed? World J Urol. 2001 Aug;19(4):251-5. doi: 10.1007/s003450000182. PMID: 11550783.
10: Shamloul R. Natural aphrodisiacs. J Sex Med. 2010 Jan;7(1 Pt 1):39-49. doi: 10.1111/j.1743-6109.2009.01521.x. Epub 2009 Sep 30. PMID: 19796015.