WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 464029

CAS#: unknown

Description: M826 is a neuroprotective agent.

Chemical Structure

CAS# unknown

Theoretical Analysis

MedKoo Cat#: 464029
Name: M826
CAS#: unknown
Chemical Formula: C28H45N7O6
Exact Mass: 575.3431
Molecular Weight: 575.711
Elemental Analysis: C, 58.42; H, 7.88; N, 17.03; O, 16.67

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: M826; M 826; M-826;

IUPAC/Chemical Name: 3-((S)-2-(5-(tert-butyl)-3-(((4-methyl-1,2,5-oxadiazol-3-yl)methyl)amino)-2-oxopyrazin-1(2H)-yl)butanamido)-5-(hexyl(methyl)amino)-4-oxopentanoic acid


InChi Code: InChI=1S/C28H45N7O6/c1-8-10-11-12-13-34(7)16-22(36)19(14-24(37)38)30-26(39)21(9-2)35-17-23(28(4,5)6)31-25(27(35)40)29-15-20-18(3)32-41-33-20/h17,19,21H,8-16H2,1-7H3,(H,29,31)(H,30,39)(H,37,38)/t19?,21-/m0/s1


Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 575.711 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Seven days in medicine: 26 Feb to 3 Mar 2020. BMJ. 2020 Mar 4;368:m826. doi: 10.1136/bmj.m826. PMID: 32139441.

2: Yu F, Song H, Wu Y, Chang SY, Wang L, Li W, Hong B, Xia S, Wang C, Khurana S, Feng Y, Wang Y, Sun Z, He B, Hou D, Manischewitz J, King LR, Song Y, Min JY, Golding H, Ji X, Lu L, Jiang S, Dimitrov DS, Ying T. A Potent Germline-like Human Monoclonal Antibody Targets a pH-Sensitive Epitope on H7N9 Influenza Hemagglutinin. Cell Host Microbe. 2017 Oct 11;22(4):471-483.e5. doi: 10.1016/j.chom.2017.08.011. Epub 2017 Sep 28. PMID: 28966056; PMCID: PMC6290738.

3: Chen H, Xu H. Poly[(μ(2)-benzene-1,3-dicarboxyl- ato-κ(2)O(1):O(3)){μ(2)-1,2-bis-[(1H-imidazol-1-yl)meth- yl]benzene-κ(2)N(3):N(3')}zinc]. Acta Crystallogr Sect E Struct Rep Online. 2012 Jun 1;68(Pt 6):m826. doi: 10.1107/S1600536812022544. Epub 2012 May 26. PMID: 22719367; PMCID: PMC3379146.

4: Han Y, Giroux A, Colucci J, Bayly CI, Mckay DJ, Roy S, Xanthoudakis S, Vaillancourt J, Rasper DM, Tam J, Tawa P, Nicholson DW, Zamboni RJ. Novel pyrazinone mono-amides as potent and reversible caspase-3 inhibitors. Bioorg Med Chem Lett. 2005 Feb 15;15(4):1173-80. doi: 10.1016/j.bmcl.2004.12.006. PMID: 15686936.

5: Toulmond S, Tang K, Bureau Y, Ashdown H, Degen S, O'Donnell R, Tam J, Han Y, Colucci J, Giroux A, Zhu Y, Boucher M, Pikounis B, Xanthoudakis S, Roy S, Rigby M, Zamboni R, Robertson GS, Ng GY, Nicholson DW, Flückiger JP. Neuroprotective effects of M826, a reversible caspase-3 inhibitor, in the rat malonate model of Huntington's disease. Br J Pharmacol. 2004 Feb;141(4):689-97. doi: 10.1038/sj.bjp.0705662. Epub 2004 Jan 26. PMID: 14744804; PMCID: PMC1574244.

6: Han BH, Xu D, Choi J, Han Y, Xanthoudakis S, Roy S, Tam J, Vaillancourt J, Colucci J, Siman R, Giroux A, Robertson GS, Zamboni R, Nicholson DW, Holtzman DM. Selective, reversible caspase-3 inhibitor is neuroprotective and reveals distinct pathways of cell death after neonatal hypoxic-ischemic brain injury. J Biol Chem. 2002 Aug 16;277(33):30128-36. doi: 10.1074/jbc.M202931200. Epub 2002 Jun 10. PMID: 12058036.