WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 463988
Description: WV970 a multikinase inhibitor (IC50 in the nanomolar range) that displays anti-influenza activity. It inhibits multiple kinases, including JAK-2, with 61% inhibition at 50 nM. Its antiviral activity is similar to that of oseltamivir carboxylate (IC50 0.012 μM), which is a currently available antiviral drug. It exhibits potent antiviral activity against the influenza A strain A/Udorn/307/1972 (H3N2) and influenza B strains B/Yamagata/16/88 and B/Nagasaki/1/87
MedKoo Cat#: 463988
Chemical Formula: C26H29N3O2S
Exact Mass: 447.198
Molecular Weight: 447.597
Elemental Analysis: C, 69.77; H, 6.53; N, 9.39; O, 7.15; S, 7.16
This product is not in stock, which may be available by custom synthesis.
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Synonym: WV970; WV 970; WV-970;
IUPAC/Chemical Name: 3-((5-cyclopropyl-4-oxo-3-((S)-1-phenylethyl)-2-thioxoimidazolidin-1-yl)methyl)-7,8-dimethyl-4a,8a-dihydroquinolin-2(1H)-one
InChi Key: AQYCLXDRDBNBAN-MUJCKVTBSA-N
InChi Code: InChI=1S/C26H29N3O2S/c1-15-9-10-20-13-21(24(30)27-22(20)16(15)2)14-28-23(19-11-12-19)25(31)29(26(28)32)17(3)18-7-5-4-6-8-18/h4-10,13,17,19-20,22-23H,11-12,14H2,1-3H3,(H,27,30)/t17-,20?,22?,23?/m0/s1
SMILES Code: O=C(N([C@@H](C)C1=CC=CC=C1)C2=S)C(C3CC3)N2CC4=CC(C=CC(C)=C5C)C5NC4=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 447.597 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Sasaki Y, Kakisaka M, Chutiwitoonchai N, Tajima S, Hikono H, Saito T, Aida Y. Identification of a novel multiple kinase inhibitor with potent antiviral activity against influenza virus by reducing viral polymerase activity. Biochem Biophys Res Commun. 2014 Jul 18;450(1):49-54. doi: 10.1016/j.bbrc.2014.05.058. Epub 2014 May 22. PMID: 24858693.