WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 413176
CAS#: 548-84-5 (Cl)
Description: Pyrvinium chloride is used in the treatment of pinworm infections
MedKoo Cat#: 413176
Name: Pyrvinium chloride
CAS#: 548-84-5 (Cl)
Chemical Formula: C26H28ClN3
Exact Mass: 417.1972
Molecular Weight: 417.98
Elemental Analysis: C, 74.71; H, 6.75; Cl, 8.48; N, 10.05
This product is not in stock, which may be available by custom synthesis.
For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge).
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Related CAS #: 110-85-0 (free base) 142-88-1 (adipate) 3546-41-6 (pamoate); 548-84-5 (Cl); 35648-29-4 (Iodide)
Synonym: Pyrvinium chloride; SN4395; SN-4395; SN 4395
IUPAC/Chemical Name: Quinolinium, 6-dimethylamino-2-(2-(2,5-dimethyl-1-phenyl-3-pyrrolyl)vinyl)-1-methyl-, chloride
InChi Key: IKUGNXPCGVYRHO-UHFFFAOYSA-M
InChi Code: InChI=1S/C26H28N3.ClH/c1-19-17-21(20(2)29(19)24-9-7-6-8-10-24)11-13-23-14-12-22-18-25(27(3)4)15-16-26(22)28(23)5;/h6-18H,1-5H3;1H/q+1;/p-1
SMILES Code: C[N+]1=C2C=CC(N(C)C)=CC2=CC=C1/C=C/C3=C(C)N(C4=CC=CC=C4)C(C)=C3.[Cl-]
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 417.98 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: PYRVINIUM chloride. J Am Med Assoc. 1957 Apr 20;163(16):1481. PMID: 13415914.
2: Zhang C, Zhang Z, Zhang S, Wang W, Hu P. Targeting of Wnt/β-Catenin by Anthelmintic Drug Pyrvinium Enhances Sensitivity of Ovarian Cancer Cells to Chemotherapy. Med Sci Monit. 2017 Jan 16;23:266-275. doi: 10.12659/msm.901667. PMID: 28090074; PMCID: PMC5266205.
3: Song P, Feng L, Li J, Dai D, Zhu L, Wang C, Li J, Li L, Zhou Q, Shi R, Wang X, Jin H. β-catenin represses miR455-3p to stimulate m6A modification of HSF1 mRNA and promote its translation in colorectal cancer. Mol Cancer. 2020 Aug 24;19(1):129. doi: 10.1186/s12943-020-01244-z. PMID: 32838807; PMCID: PMC7446108.
4: BECK JW, SAAVEDRA D, ANTELL GJ, TEJEIRO B. The treatment of pinworm infections in humans (enterobiasis) with pyrvinium chloride and pyrvinium pamoate. Am J Trop Med Hyg. 1959 May;8(3):349-52. doi: 10.4269/ajtmh.1959.8.349. PMID: 13661537.
5: METZL K. A case of strongyloidiasis treated with pyrvinium chloride. Am J Trop Med Hyg. 1963 Mar;12:209-10. doi: 10.4269/ajtmh.1963.12.209. PMID: 13935222.
6: Mehta RD, Hennig UG, von Borstel RC, Chatten LG. Genetic activity in Saccharomyces cerevisiae and thin-layer chromatographic comparisons of medical grades of pyrvinium pamoate and monopyrvinium salts. Mutat Res. 1982 Jul- Aug;102(1):59-69. doi: 10.1016/0165-1218(82)90146-x. PMID: 6750373.
7: BUMBALO TS, PLUMMER LJ, WARNER JR. The treatment of enterobiasis in children. A comparative study of piperazine (antepar) and pyrvinium chloride (vanquin). Am J Trop Med Hyg. 1958 Mar;7(2):212-4. doi: 10.4269/ajtmh.1958.7.212. PMID: 13533727.
8: Jeon KI, Phipps RP, Sime PJ, Huxlin KR. Antifibrotic Actions of Peroxisome Proliferator-Activated Receptor γ Ligands in Corneal Fibroblasts Are Mediated by β-Catenin-Regulated Pathways. Am J Pathol. 2017 Aug;187(8):1660-1669. doi: 10.1016/j.ajpath.2017.04.002. Epub 2017 Jun 10. PMID: 28606794; PMCID: PMC5530905.
9: SAWITZ WG, KARPINSKI FE Jr. Treatment of oxyuriasis with pyrrovinyquinium chloride (poquil). Am J Trop Med Hyg. 1956 May;5(3):538-43. doi: 10.4269/ajtmh.1956.5.538. PMID: 13327191.
10: Barclay BJ, DeHaan CL, Hennig UG, Iavorovska O, von Borstel RW, von Borstel RC. A rapid assay for mitochondrial DNA damage and respiratory chain inhibition in the yeast Saccharomyces cerevisiae. Environ Mol Mutagen. 2001;38(2-3):153-8. doi: 10.1002/em.1066. PMID: 11746749.
