Mazipredone HCl

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 463959

CAS#: 60-39-9 (HCl)

Description: Mazipredone HCl, also known as Depersolone, is a synthetic glucocorticoid corticosteroid which is or has been marketed in the Czech Republic and Hungary.

Chemical Structure

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Mazipredone HCl
CAS# 60-39-9 (HCl)
Instruction

Theoretical Analysis

MedKoo Cat#: 463959
Name: Mazipredone HCl
CAS#: 60-39-9 (HCl)
Chemical Formula: C26H39ClN2O4
Exact Mass: 478.26
Molecular Weight: 479.058
Elemental Analysis: C, 65.19; H, 8.21; Cl, 7.40; N, 5.85; O, 13.36

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: Mazipredone HCl; Depersolone;

IUPAC/Chemical Name: (8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-10,13-dimethyl-17-(2-(4-methylpiperazin-1-yl)acetyl)-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one hydrochloride

InChi Key: OHMBNBZVSGNWEE-HEBJBRBZSA-N

InChi Code: InChI=1S/C26H38N2O4.ClH/c1-24-8-6-18(29)14-17(24)4-5-19-20-7-9-26(32,25(20,2)15-21(30)23(19)24)22(31)16-28-12-10-27(3)11-13-28;/h6,8,14,19-21,23,30,32H,4-5,7,9-13,15-16H2,1-3H3;1H/t19-,20-,21-,23+,24-,25-,26-;/m0./s1

SMILES Code: CN1CCN(CC1)CC([C@]2(CC[C@H]3[C@@H]4CCC5=CC(C=C[C@@]5([C@H]4[C@H](C[C@]23C)O)C)=O)O)=O.Cl

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 479.06 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Görög S. The paradigm shifting role of chromatographic methods in pharmaceutical analysis. J Pharm Biomed Anal. 2012 Oct;69:2-8. doi: 10.1016/j.jpba.2012.01.031. Epub 2012 Jan 30. PMID: 22341481.

2: Görög S, Babják M, Balogh G, Brlik J, Csehi A, Dravecz F, Gasdag M, Horváth P, Laukó A, Varga K. Drug impurity profiling strategies. Talanta. 1997 Sep;44(9):1517-26. PMID: 18966892.

3: Görög S, Babják M, Balogh G, Brlik J, Dravecz F, Gazdag M, Horváth P, Laukó A, Varga K. Estimation of impurity profiles of drugs and related materials: part 19: theme with variations. Identification of impurities in 3-oxosteroids. J Pharm Biomed Anal. 1998 Dec;18(4-5):511-25. doi: 10.1016/s0731-7085(98)00206-4. PMID: 9919951.

4: Gazdag M, Babják M, Brlik J, Mahó S, Tuba Z, Görög S. Estimation of impurity profiles of drugs and related materials Part 18. Impurities and degradation products of mazipredone. J Pharm Biomed Anal. 1998 Sep 1;17(6-7):1029-36. doi: 10.1016/s0731-7085(98)00068-5. PMID: 9884192.

5: Kiss G, Radványi S, Szigeti G, Lukáts B, Nagy G. New combination for the therapy of canine otitis externa. II. Efficacy in vitro and in vivo. J Small Anim Pract. 1997 Feb;38(2):57-60. doi: 10.1111/j.1748-5827.1997.tb02988.x. PMID: 9065883.

6: Görög S, Balogh G, Csehi A, Csizér E, Gazdag M, Halmos Z, Hegedüs B, Herényi B, Horváth P, Laukó A. Estimation of impurity profiles in drugs and related materials. Part 11--The role of chromatographic and spectroscopic methods in the estimation of side-reactions in drug syntheses. J Pharm Biomed Anal. 1993 Nov- Dec;11(11-12):1219-26. doi: 10.1016/0731-7085(93)80107-c. PMID: 8123737.

7: LUKATS B, TAKACSINAGY G. AZ O-DINITROBENZOLOS SZ'INREAKCI'O 'ES ANNAK ALKALMAZ'ASA EGYES SZTEROID VEGYUELETEK M'ER'ES'ERE 'ES A DEPERSOLONR STABILIT'ASI VIZSG'ALAT'ARA [COLOR REACTION OF O-DINITROBENZENE AND ITS USE IN MEASURING SOME STEROID COMPOUNDS AND IN THE STUDY OF THE STABILITY OF DEPERSOLONE]. Acta Pharm Hung. 1965 May;35:116-22. Hungarian. PMID: 14313169.