WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 463947
CAS#: 677746-25-7
Description: K162 is a novel Inhibitor of Amyloid β-Induced Lipid Membrane Permeation and Amyloid β Aggregation.
MedKoo Cat#: 463947
Name: K162
CAS#: 677746-25-7
Chemical Formula: C15H14BrN
Exact Mass: 287.031
Molecular Weight: 288.188
Elemental Analysis: C, 62.52; H, 4.90; Br, 27.73; N, 4.86
This product is not in stock, which may be available by custom synthesis.
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Synonym: K162; K 162; K-162; K01-162; K01162; K01 162;
IUPAC/Chemical Name: 7-bromo-N,N-dimethyl-9H-fluoren-2-amine
InChi Key: KABXKWWJTYSDTD-UHFFFAOYSA-N
InChi Code: InChI=1S/C15H14BrN/c1-17(2)13-4-6-15-11(9-13)7-10-8-12(16)3-5-14(10)15/h3-6,8-9H,7H2,1-2H3
SMILES Code: CN(C)C1=CC(CC2=C3C=CC(Br)=C2)=C3C=C1
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 288.188 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1. Mrdenovic D, Zarzycki P, Majewska M, Pieta IS, Nowakowski R, Kutner W, Lipkowski J, Pieta P. Inhibition of Amyloid β-Induced Lipid Membrane Permeation and Amyloid β Aggregation by K162. ACS Chem Neurosci. 2021 Jan 22. doi: 10.1021/acschemneuro.0c00754. Epub ahead of print. PMID: 33478212.
