FB23 inhibitor
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 555906

CAS#: 2243736-35-6

Description: FB23 is a potent and selective inhibitor of N6-methyladenosine (m6A) demethylase FTO (fat mass and obesity associated protein). It moderately inhibits proliferation of NB4 and MONOMAC6 cells. FB23 demonstrates its potent inhibitory impact in AML models.

Chemical Structure

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FB23 inhibitor
CAS# 2243736-35-6
Instruction

Theoretical Analysis

MedKoo Cat#: 555906
Name: FB23 inhibitor
CAS#: 2243736-35-6
Chemical Formula: C18H14Cl2N2O3
Exact Mass: 376.04
Molecular Weight: 377.221
Elemental Analysis: C, 57.31; H, 3.74; Cl, 18.80; N, 7.43; O, 12.72

Price and Availability

Size Price Availability Quantity
100mg USD 1450 2 Weeks
200mg USD 2150 2 Weeks
500mg USD 2950 2 Weeks
1g USD 3950 2 Weeks
2g USD 6970 2 Weeks
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Synonym: FB23 inhibitor; FB-23; FB 23;

IUPAC/Chemical Name: 2-[[2,6-Dichloro-4-(3,5-dimethyl-4-isoxazolyl)phenyl]amino]benzoic acid

InChi Key: VUXZATVQMFSUCM-UHFFFAOYSA-N

InChi Code: InChI=1S/C18H14Cl2N2O3/c1-9-16(10(2)25-22-9)11-7-13(19)17(14(20)8-11)21-15-6-4-3-5-12(15)18(23)24/h3-8,21H,1-2H3,(H,23,24)

SMILES Code: O=C(O)C1=CC=CC=C1NC2=C(Cl)C=C(C3=C(C)ON=C3C)C=C2Cl

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 377.22 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Zhao T, Wang J, Wu Y, Han L, Chen J, Wei Y, Shen L, Long C, Wu S, Wei G. Increased m6A modification of RNA methylation related to the inhibition of demethylase FTO contributes to MEHP-induced Leydig cell injury☆. Environ Pollut. 2021 Jan 1;268(Pt A):115627. doi: 10.1016/j.envpol.2020.115627. Epub 2020 Sep 24. PMID: 33010548.


2: Yu J, Zhang Y, Ma H, Zeng R, Liu R, Wang P, Jin X, Zhao Y. Epitranscriptomic profiling of N6-methyladenosine-related RNA methylation in rat cerebral cortex following traumatic brain injury. Mol Brain. 2020 Jan 28;13(1):11. doi: 10.1186/s13041-020-0554-0. PMID: 31992337; PMCID: PMC6986156.


3: Huang Y, Su R, Sheng Y, Dong L, Dong Z, Xu H, Ni T, Zhang ZS, Zhang T, Li C, Han L, Zhu Z, Lian F, Wei J, Deng Q, Wang Y, Wunderlich M, Gao Z, Pan G, Zhong D, Zhou H, Zhang N, Gan J, Jiang H, Mulloy JC, Qian Z, Chen J, Yang CG. Small- Molecule Targeting of Oncogenic FTO Demethylase in Acute Myeloid Leukemia. Cancer Cell. 2019 Apr 15;35(4):677-691.e10. doi: 10.1016/j.ccell.2019.03.006. PMID: 30991027; PMCID: PMC6812656.


4: Van Der Werf I, Jamieson C. The Yin and Yang of RNA Methylation: An Imbalance of Erasers Enhances Sensitivity to FTO Demethylase Small-Molecule Targeting in Leukemia Stem Cells. Cancer Cell. 2019 Apr 15;35(4):540-541. doi: 10.1016/j.ccell.2019.03.011. PMID: 30991023.


5: Liu J, Meng Y, Lv F, Chen J, Ma Y, Wang Y, Chen B, Zhang L, Zhou Z. Photosynthetic characteristics of the subtending leaf of cotton boll at different fruiting branch nodes and their relationships with lint yield and fiber quality. Front Plant Sci. 2015 Sep 17;6:747. doi: 10.3389/fpls.2015.00747. PMID: 26442060; PMCID: PMC4584985.


6: Kuai J, Liu Z, Wang Y, Meng Y, Chen B, Zhao W, Zhou Z, Oosterhuis DM. Waterlogging during flowering and boll forming stages affects sucrose metabolism in the leaves subtending the cotton boll and its relationship with boll weight. Plant Sci. 2014 Jun;223:79-98. doi: 10.1016/j.plantsci.2014.03.010. Epub 2014 Mar 15. PMID: 24767118.


7: Okitsu SL, Boato F, Mueller MS, Li DB, Vogel D, Westerfeld N, Zurbriggen R, Robinson JA, Pluschke G. Antibodies elicited by a virosomally formulated Plasmodium falciparum serine repeat antigen-5 derived peptide detect the processed 47 kDa fragment both in sporozoites and merozoites. Peptides. 2007 Oct;28(10):2051-60. doi: 10.1016/j.peptides.2007.08.007. Epub 2007 Aug 17. PMID: 17875342.


8: Zhang B, Wang Q, Wang K, Pan X, Liu F, Guo T, Cobb GP, Anderson TA. Identification of cotton microRNAs and their targets. Gene. 2007 Aug 1;397(1-2):26-37. doi: 10.1016/j.gene.2007.03.020. Epub 2007 Apr 20. PMID: 17574351