M-527301

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 575846

CAS#: 1221965-74-7

Description: M-527301 is a metabolite of Gefitinib.


Chemical Structure

img
M-527301
CAS# 1221965-74-7

Theoretical Analysis

MedKoo Cat#: 575846
Name: M-527301
CAS#: 1221965-74-7
Chemical Formula: C18H17ClFN3O3
Exact Mass: 377.0942
Molecular Weight: 377.8
Elemental Analysis: C, 57.23; H, 4.54; Cl, 9.38; F, 5.03; N, 11.12; O, 12.70

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: Gefitinib metabolite M-527301; M-527301; M 527301; M527301

IUPAC/Chemical Name: 3-(4-(3-Chloro-4-fluoro-anilino)-7-methoxy-quinazolin-6-yl)oxypropan-1-ol

InChi Key: AMLVQRCDTNBYLW-UHFFFAOYSA-N

InChi Code: 1S/C18H17ClFN3O3/c1-25-16-9-15-12(8-17(16)26-6-2-5-24)18(22-10-21-15)23-11-3-4-14(20)13(19)7-11/h3-4,7-10,24H,2,5-6H2,1H3,(H,21,22,23)

SMILES Code: COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1OCCCO

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 377.8 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

1. Zhao C, Zheng N, Yang F, Han SY, Li PP. A validated high-performance liquid chromatography-tandem mass spectrometry method for quantification of gefitinib and its main metabolites in xenograft mouse tumor: Application to a pharmacokinetics study. Biomed Chromatogr. 2019 Nov;33(11):e4638. doi: 10.1002/bmc.4638. Epub 2019 Aug 13. PMID: 31261446.

2. Guan S, Chen X, Wang F, Xin S, Feng W, Zhu X, Liu S, Zhuang W, Zhou S, Huang M, Wang X, Zhang L. Development and validation of a sensitive LC-MS/MS method for determination of gefitinib and its major metabolites in human plasma and its application in non-small cell lung cancer patients. J Pharm Biomed Anal. 2019 Aug 5;172:364-371. doi: 10.1016/j.jpba.2019.03.060. Epub 2019 Mar 28. PMID: 31096095.