WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 575844
Description: M-387783 is a metabolite of Gefitinib.
MedKoo Cat#: 575844
Chemical Formula: C22H25ClN4O4
Exact Mass: 444.1564
Molecular Weight: 444.92
Elemental Analysis: C, 59.39; H, 5.66; Cl, 7.97; N, 12.59; O, 14.38
This product is not in stock, which may be available by custom synthesis.
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Synonym: Gefitinib metabolite M-387783; M-387783; M 387783; M387783
IUPAC/Chemical Name: 2-Chloro-4-((7-methoxy-6-(3-morpholinopropoxy)quinazolin-4-yl)amino)phenol
InChi Key: IQWXTDMHBQBADK-UHFFFAOYSA-N
InChi Code: 1S/C22H25ClN4O4/c1-29-20-13-18-16(12-21(20)31-8-2-5-27-6-9-30-10-7-27)22(25-14-24-18)26-15-3-4-19(28)17(23)11-15/h3-4,11-14,28H,2,5-10H2,1H3,(H,24,25,26)
SMILES Code: COc1cc2ncnc(Nc3ccc(O)c(Cl)c3)c2cc1OCCCN4CCOCC4
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 444.92 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1. Zhao C, Zheng N, Yang F, Han SY, Li PP. A validated high-performance liquid chromatography-tandem mass spectrometry method for quantification of gefitinib and its main metabolites in xenograft mouse tumor: Application to a pharmacokinetics study. Biomed Chromatogr. 2019 Nov;33(11):e4638. doi: 10.1002/bmc.4638. Epub 2019 Aug 13. PMID: 31261446.
2. Guan S, Chen X, Wang F, Xin S, Feng W, Zhu X, Liu S, Zhuang W, Zhou S, Huang M, Wang X, Zhang L. Development and validation of a sensitive LC-MS/MS method for determination of gefitinib and its major metabolites in human plasma and its application in non-small cell lung cancer patients. J Pharm Biomed Anal. 2019 Aug 5;172:364-371. doi: 10.1016/j.jpba.2019.03.060. Epub 2019 Mar 28. PMID: 31096095.