WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 413043

CAS#: 1931994-81-8

Description: Zabedosertib, also known as BAY 1834845, is a IRAK-4 inhibitor. IRAK-4 inhibitors are an exciting therapeutic option in RA management because unlike other targeted disease-modifying agents, they target the innate immune system. The role of IRAK-4 as a key component of Toll/Interleukin-1 receptor signaling and its potential for a low rate of infectious complications is particularly exciting and this may facilitate their use in combination treatment.

Chemical Structure

CAS# 1931994-81-8

Theoretical Analysis

MedKoo Cat#: 413043
Name: Zabedosertib
CAS#: 1931994-81-8
Chemical Formula: C20H21F3N4O4S
Exact Mass: 470.12
Molecular Weight: 470.470
Elemental Analysis: C, 51.06; H, 4.50; F, 12.11; N, 11.91; O, 13.60; S, 6.81

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales or click below button.
Note: Price will be listed if it is available in the future.

Synonym: Zabedosertib; BAY 1834845; BAY1834845; BAY-1834845;

IUPAC/Chemical Name: N-{6-(2-hydroxypropan-2-yl)-2-[2-(methanesulfonyl)ethyl]- 2H-indazol-5-yl}-6-(trifluoromethyl)pyridine-2- carboxamide


InChi Code: InChI=1S/C20H21F3N4O4S/c1-19(2,29)13-10-15-12(11-27(26-15)7-8-32(3,30)31)9-16(13)25-18(28)14-5-4-6-17(24-14)20(21,22)23/h4-6,9-11,29H,7-8H2,1-3H3,(H,25,28)

SMILES Code: O=C(C1=NC(C(F)(F)F)=CC=C1)NC2=CC3=CN(CCS(=O)(C)=O)N=C3C=C2C(C)(O)C

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Product Data:

Preparing Stock Solutions

The following data is based on the product molecular weight 470.470000000000000000000000000000 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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