Ispronicline hemigalactarate

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 575776

CAS#: 252870-54-5

Description: Ispronicline hemigalactarate is a neuronal nicotinic acetylcholine receptor partial agonist.

Chemical Structure

Ispronicline hemigalactarate
CAS# 252870-54-5

Theoretical Analysis

MedKoo Cat#: 575776
Name: Ispronicline hemigalactarate
CAS#: 252870-54-5
Chemical Formula: C34H54N4O10
Exact Mass: 678.384
Molecular Weight: 678.82
Elemental Analysis: C, 60.16; H, 8.02; N, 8.25; O, 23.57

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: Ispronicline hemigalactarate

IUPAC/Chemical Name: Galactaric acid, compd. with (2S,4E)-N-methyl-5-(5-(1-methylethoxy)-3-pyridinyl)-4-penten-2-amine (1:2)


InChi Code: InChI=1S/2C14H22N2O.C6H10O8/c2*1-11(2)17-14-8-13(9-16-10-14)7-5-6-12(3)15-4;7-1(3(9)5(11)12)2(8)4(10)6(13)14/h2*5,7-12,15H,6H2,1-4H3;1-4,7-10H,(H,11,12)(H,13,14)/b2*7-5+;/t2*12-;1-,2+,3+,4-/m00./s1

SMILES Code: CN[C@@H](C)C\C=C\c1cncc(OC(C)C)c1.CN[C@@H](C)C\C=C\c2cncc(OC(C)C)c2.O[C@H]([C@H](O)[C@@H](O)C(=O)O)[C@H](O)C(=O)O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 678.82 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1. Dunbar GC, Inglis F, Kuchibhatla R, Sharma T, Tomlinson M, Wamsley J. Effect of ispronicline, a neuronal nicotinic acetylcholine receptor partial agonist, in subjects with age associated memory impairment (AAMI). J Psychopharmacol. 2007 Mar;21(2):171-8. doi: 10.1177/0269881107066855. Erratum in: J Psychopharmacol. 2008 Aug;22(6):698. PMID: 17329297.

2. Lippiello P, Letchworth SR, Gatto GJ, Traina VM, Bencherif M. Ispronicline: a novel alpha4beta2 nicotinic acetylcholine receptor-selective agonist with cognition-enhancing and neuroprotective properties. J Mol Neurosci. 2006;30(1-2):19-20. doi: 10.1385/JMN:30:1:19. PMID: 17192610.

3. Dunbar G, Demazières A, Monreal A, Cisterni C, Metzger D, Kuchibhatla R, Luthringer R. Pharmacokinetics and safety profile of ispronicline (TC-1734), a new brain nicotinic receptor partial agonist, in young healthy male volunteers. J Clin Pharmacol. 2006 Jul;46(7):715-26. doi: 10.1177/0091270006288730. PMID: 16809797.