WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 575769
Description: Gacyclidine hydrochloride is a N-methyl-D-aspartate (NMDA) receptor antagonist potentially for the treatment of tinnitus.
MedKoo Cat#: 575769
Name: Gacyclidine hydrochloride
Chemical Formula: C16H26ClNS
Exact Mass: 299.1474
Molecular Weight: 299.9
Elemental Analysis: C, 64.08; H, 8.74; Cl, 11.82; N, 4.67; S, 10.69
This product is not in stock, which may be available by custom synthesis.
For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge).
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Synonym: (+/-)-Gacyclidine hydrochloride; Gacyclidine hydrochloride; Gacyclidine HCl
IUPAC/Chemical Name: Piperidine, 1-(2-methyl-1-(2-thienyl)cyclohexyl)-, hydrochloride, cis-
InChi Key: AJPKYPDCAXFLDK-KUARMEPBSA-N
InChi Code: InChI=1S/C16H25NS.ClH/c1-14-8-3-4-10-16(14,15-9-7-13-18-15)17-11-5-2-6-12-17;/h7,9,13-14H,2-6,8,10-12H2,1H3;1H/t14-,16+;/m0./s1
SMILES Code: Cl.C[C@H]1CCCC[C@]1(N2CCCCC2)c3cccs3
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 299.9 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Chenoweth JA, Gerona RR, Ford JB, Sutter ME, Rose JS, Albertson TE, Clarke SO, Owen KP. Altered mental status and end organ damage associated with the use of gacyclidine: a case series. J Med Toxicol. 2015 Mar;11(1):115-20. doi: 10.1007/s13181-014-0415-2. PubMed PMID: 25048606; PubMed Central PMCID: PMC4371039.
2: Wenzel GI, Warnecke A, Stöver T, Lenarz T. Effects of extracochlear gacyclidine perfusion on tinnitus in humans: a case series. Eur Arch Otorhinolaryngol. 2010 May;267(5):691-9. doi: 10.1007/s00405-009-1126-1. PubMed PMID: 19847455.
3: Gerber YN, Privat A, Perrin FE. Gacyclidine improves the survival and reduces motor deficits in a mouse model of amyotrophic lateral sclerosis. Front Cell Neurosci. 2013 Dec 27;7:280. doi: 10.3389/fncel.2013.00280. PubMed PMID: 24409117; PubMed Central PMCID: PMC3873512.
4: Hoizey G, Kaltenbach ML, Dukic S, Lamiable D, Millart H, D'Arbigny P, Vistelle R. Pharmacokinetics of gacyclidine enantiomers in plasma and spinal cord after single enantiomer administration in rats. Int J Pharm. 2001 Oct 23;229(1-2):147-53. PubMed PMID: 11604267.
5: Hirbec H, Gaviria M, Vignon J. Gacyclidine: a new neuroprotective agent acting at the N-methyl-D-aspartate receptor. CNS Drug Rev. 2001 Summer;7(2):172-98. Review. PubMed PMID: 11474423.