Gaboxadol hydrobromide

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 575767

CAS#: 65202-63-3

Description: Gaboxadol hydrobromide is a GABA agonist. It is an inhibitor of GABA uptake systems. Gaboxadol can also be a non-opioid analgesic and a novel type of hypnotic.


Chemical Structure

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Gaboxadol hydrobromide
CAS# 65202-63-3

Theoretical Analysis

MedKoo Cat#: 575767
Name: Gaboxadol hydrobromide
CAS#: 65202-63-3
Chemical Formula: C6H9BrN2O2
Exact Mass: 219.9847
Molecular Weight: 221.05
Elemental Analysis: C, 32.60; H, 4.10; Br, 36.15; N, 12.67; O, 14.48

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: Gaboxadol hydrobromide; Gaboxadol HBr; THIP monohydrobromide

IUPAC/Chemical Name: Isoxazolo(5,4-c)pyridin-3(2H)-one, 4,5,6,7-tetrahydro-, monohydrobromide

InChi Key: UPVZCNRBPOAABW-UHFFFAOYSA-N

InChi Code: InChI=1S/C6H8N2O2.BrH/c9-6-4-1-2-7-3-5(4)10-8-6;/h7H,1-3H2,(H,8,9);1H

SMILES Code: Br.O=C1NOC2=C1CCNC2

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 221.05 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Silverman NS, Popp S, Vialou V, Astafurov K, Nestler EJ, Dow-Edwards D. Effects of gaboxadol on the expression of cocaine sensitization in rats. Exp Clin Psychopharmacol. 2016 Apr;24(2):131-41. doi: 10.1037/pha0000069. Epub 2016 Feb 22. PubMed PMID: 26901591.

2: Zanettini C, Pressly JD, Ibarra MH, Smith KR, Gerak LR. Comparing the discriminative stimulus effects of modulators of GABAA receptors containing α4-δ subunits with those of gaboxadol in rats. Psychopharmacology (Berl). 2016 May;233(10):2005-13. doi: 10.1007/s00213-016-4243-8. Epub 2016 Feb 22. PubMed PMID: 26900079.

3: Kesisoglou F, Balakrishnan A, Manser K. Utility of PBPK Absorption Modeling to Guide Modified Release Formulation Development of Gaboxadol, a Highly Soluble Compound With Region-Dependent Absorption. J Pharm Sci. 2016 Feb;105(2):722-8. doi: 10.1002/jps.24674. Epub 2016 Jan 11. PubMed PMID: 26457884.

4: Ramaker MJ, Strong-Kaufman MN, Ford MM, Phillips TJ, Finn DA. Effect of nucleus accumbens shell infusions of ganaxolone or gaboxadol on ethanol consumption in mice. Psychopharmacology (Berl). 2015 Apr;232(8):1415-26. doi: 10.1007/s00213-014-3777-x. Epub 2014 Oct 25. PubMed PMID: 25342197; PubMed Central PMCID: PMC4412309.

5: Fritz BM, Boehm SL 2nd. Site-specific microinjection of Gaboxadol into the infralimbic cortex modulates ethanol intake in male C57BL/6J mice. Behav Brain Res. 2014 Oct 15;273:8-15. doi: 10.1016/j.bbr.2014.07.020. Epub 2014 Jul 18. PubMed PMID: 25043731; PubMed Central PMCID: PMC4152776.