Maprotiline-d3 hydrochloride

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MedKoo CAT#: 463869

CAS#: 1329496-63-0 (hydrochloride)

Description: Maprotiline-d3 is intended for use as an internal standard for the quantification of maprotiline by GC- or LC-MS. Maprotiline is a tricyclic antidepressant. It binds to the norepinephrine transporter (NET) and is selective for NET over the serotonin and dopamine transporters. Maprotiline also binds to the serotonin (5-HT) receptor subtype 5-HT2A, as well as histamine H1, muscarinic acetylcholine, α1-adrenergic, and dopamine D2 receptors. In vivo, maprotiline inhibits norepinephrine reuptake in rat brain and peripheral tissues. It reduces isolation-induced aggressive behavior and inhibits electrical foot-shock stimulation-induced belligerence in mice when administered at doses ranging from 3 to 10 mg/kg. Maprotiline also reduces aggressive behavior in rhesus monkeys housed in groups. Formulations containing maprotiline have been used in the treatment of depression and anxiety.

Chemical Structure

Maprotiline-d3 hydrochloride
CAS# 1329496-63-0 (hydrochloride)

Theoretical Analysis

MedKoo Cat#: 463869
Name: Maprotiline-d3 hydrochloride
CAS#: 1329496-63-0 (hydrochloride)
Chemical Formula: C20H21D3ClN
Exact Mass: 316.1786
Molecular Weight: 316.8873
Elemental Analysis: C, 75.81; H, 8.59; Cl, 11.19; N, 4.42

Price and Availability

Size Price Availability Quantity
1.0mg USD 370.0 2 Weeks
5.0mg USD 1130.0 2 Weeks
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Synonym: Maprotiline-d3 hydrochloride; Maprotiline d3 hydrochloride; Ba 34276-d3; Ba34276-d3; Ba-34276-d3; Ba 34276 d3;

IUPAC/Chemical Name: 3-(9,10-ethanoanthracen-9(10H)-yl)-N-(methyl-d3)propan-1-amine hydrochloride


InChi Code: InChI=1S/C20H23N.ClH/c1-21-14-6-12-20-13-11-15(16-7-2-4-9-18(16)20)17-8-3-5-10-19(17)20;/h2-5,7-10,15,21H,6,11-14H2,1H3;1H/i1D3;

SMILES Code: [2H]C([2H])(NCCCC12CCC(C3=C2C=CC=C3)C4=CC=CC=C14)[2H].Cl

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 316.8873 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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