WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 575755
Description: G-4120 is a biochemical that has been shown to have a dose-dependent complete inhibition of arterial and venous thrombosis.
MedKoo Cat#: 575755
Chemical Formula: C26H36N8O11S
Exact Mass: 668.2224
Molecular Weight: 668.68
Elemental Analysis: C, 46.70; H, 5.43; N, 16.76; O, 26.32; S, 4.79
This product is not in stock, which may be available by custom synthesis.
For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge).
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Synonym: G 4120; G-4120; G4120
IUPAC/Chemical Name: (3R,6S,12S,15R)-6-(carboxymethyl)-12-(3-guanidinopropyl)-15-(4-hydroxybenzyl)-5,8,11,14,17-pentaoxo-1-thia-4,7,10,13,16-pentaazacyclooctadecane-3-carboxylic acid 1-oxide
InChi Key: DMXRDQJVBMEHPP-OREKCURGSA-N
InChi Code: InChI=1S/C26H36N8O11S/c27-26(28)29-7-1-2-15-22(40)30-10-19(36)31-17(9-21(38)39)24(42)34-18(25(43)44)11-46(45)12-20(37)32-16(23(41)33-15)8-13-3-5-14(35)6-4-13/h3-6,15-18,35H,1-2,7-12H2,(H,30,40)(H,31,36)(H,32,37)(H,33,41)(H,34,42)(H,38,39)(H,43,44)(H4,27,28,29)/t15-,16+,17-,18-,46?/m0/s1
SMILES Code: NC(=N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CS(=O)C[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)CNC1=O)C(=O)O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 668.68 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1. Stockmans F, Stassen JM, Vermylen J, Hoylaerts MF, Nyström A. A technique to investigate microvascular mural thrombus formation in arteries and veins: II. Effects of aspirin, heparin, r-hirudin, and G-4120. Ann Plast Surg. 1997 Jan;38(1):63-8. doi: 10.1097/00000637-199701000-00012. PMID: 9015542.
2. Barker PL, Bullens S, Bunting S, Burdick DJ, Chan KS, Deisher T, Eigenbrot C, Gadek TR, Gantzos R, Lipari MT, et al. Cyclic RGD peptide analogues as antiplatelet antithrombotics. J Med Chem. 1992 May 29;35(11):2040-8. doi: 10.1021/jm00089a014. PMID: 1597855.