Opipramol hydrochloride

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 575747

CAS#: 909-39-7 (HCl)

Description: Opipramol hydrochloride is an atypical anxiolytic and antidepressant drug chemically similar to tricyclic antidepressants. Opipramol mainly acts on sigma receptors such as histamine, serotonin, dopamine and alpha-1 adrenergic receptors.

Chemical Structure

Opipramol hydrochloride
CAS# 909-39-7 (HCl)

Theoretical Analysis

MedKoo Cat#: 575747
Name: Opipramol hydrochloride
CAS#: 909-39-7 (HCl)
Chemical Formula: C23H31Cl2N3O
Exact Mass: 435.1844
Molecular Weight: 436.42
Elemental Analysis: C, 63.30; H, 7.16; Cl, 16.25; N, 9.63; O, 3.67

Price and Availability

Size Price Availability Quantity
25.0mg USD 280.0 2 Weeks
100.0mg USD 760.0 2 Weeks
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Related CAS #: 315-72-0 (free base)   909-39-7 (HCl)  

Synonym: Ensidon; G 33040; G33040; G-33040; Insidon; Opipramol dihydrochloride; Opipramol hydrochloride; Opipramol HCl; Pramolan

IUPAC/Chemical Name: 4-(3-(5H-Dibenz(b,f)azepin-5-yl)propyl)piperazine-1-ethanol dihydrochloride


InChi Code: InChI=1S/C23H29N3O.2ClH/c27-19-18-25-16-14-24(15-17-25)12-5-13-26-22-8-3-1-6-20(22)10-11-21-7-2-4-9-23(21)26;;/h1-4,6-11,27H,5,12-19H2;2*1H

SMILES Code: Cl.Cl.OCCN1CCN(CCCN2c3ccccc3C=Cc4ccccc24)CC1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 436.42 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1. Bandelow B, Reitt M, Röver C, Michaelis S, Görlich Y, Wedekind D. Efficacy of treatments for anxiety disorders: a meta-analysis. Int Clin Psychopharmacol. 2015 Jul;30(4):183-92. doi: 10.1097/YIC.0000000000000078. PMID: 25932596.

2. Krysta K, Murawiec S, Warchala A, Zawada K, Cubała WJ, Wiglusz MS, Jakuszkowiak-Wojten K, Krzystanek M, Krupka-Matuszczyk I. Modern indications for the use of opipramol. Psychiatr Danub. 2015 Sep;27 Suppl 1:S435-7. PMID: 26417811.

3. Carpéné C, Les F, Mercader J, Gomez-Zorita S, Grolleau JL, Boulet N, Fontaine J, Iglesias-Osma MC, Garcia-Barrado MJ. Opipramol Inhibits Lipolysis in Human Adipocytes without Altering Glucose Uptake and Differently from Antipsychotic and Antidepressant Drugs with Adverse Effects on Body Weight Control. Pharmaceuticals (Basel). 2020 Mar 5;13(3):41. doi: 10.3390/ph13030041. PMID: 32151075; PMCID: PMC7151722.