Cytochalasin B

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MedKoo CAT#: 463834

CAS#: 14930-96-2

Description: Cytochalasin B is a natural inhibitor of actin polymerization and glucose transporter (GLUT).

Chemical Structure

Cytochalasin B
CAS# 14930-96-2

Theoretical Analysis

MedKoo Cat#: 463834
Name: Cytochalasin B
CAS#: 14930-96-2
Chemical Formula: C29H37NO5
Exact Mass: 479.2672
Molecular Weight: 479.617
Elemental Analysis: C, 72.62; H, 7.78; N, 2.92; O, 16.68

Price and Availability

Size Price Availability Quantity
1.0mg USD 250.0 2 Weeks
5.0mg USD 590.0 2 Weeks
10.0mg USD 890.0 2 Weeks
25.0mg USD 1520.0 2 Weeks
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Synonym: Cytochalasin B; Cytochalasin-B;

IUPAC/Chemical Name: (3E,5R,9R,11E,12aS,13S,15S,15aS,16S,18aS)-16-benzyl-5,13-dihydroxy-9,15-dimethyl-14-methylene-6,7,8,9,10,12a,13,14,15,15a,16,17-dodecahydro-2H-[1]oxacyclotetradecino[2,3-d]isoindole-2,18(5H)-dione


InChi Code: InChI=1S/C29H37NO5/c1-18-9-7-13-22(31)15-16-25(32)35-29-23(14-8-10-18)27(33)20(3)19(2)26(29)24(30-28(29)34)17-21-11-5-4-6-12-21/h4-6,8,11-12,14-16,18-19,22-24,26-27,31,33H,3,7,9-10,13,17H2,1-2H3,(H,30,34)/b14-8+,16-15+/t18-,19-,22-,23+,24+,26+,27-,29-/m1/s1

SMILES Code: O=C(/C=C/[C@H](O)CCC[C@@H](C)C/C=C/[C@@]1([H])[C@H](O)C([C@@H](C)[C@@]2([H])[C@H](CC3=CC=CC=C3)N4)=C)O[C@]12C4=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 479.617 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Ogawa T, Sasaki A, Ono K, Ohshika S, Ishibashi Y, Yamada K. Uptake of fluorescent D- and L-glucose analogues, 2-NBDG and 2-NBDLG, into human osteosarcoma U2OS cells in a phloretin-inhibitable manner. Hum Cell. 2021 Jan 17. doi: 10.1007/s13577-020-00483-y. Epub ahead of print. PMID: 33454890.

2: Jagetia GC. Antioxidant Activity of Curcumin Protects against the Radiation- Induced Micronuclei Formation in Cultured Human Peripheral Blood Lymphocytes Exposed to Various Doses of γ-Radiation. Int J Radiat Biol. 2021 Jan 19:1-32. doi: 10.1080/09553002.2021.1876948. Epub ahead of print. PMID: 33464136.

3: Michonneau P, Fleurat-Lessard P, Cantereau A, Crépin A, Roblin G, Berjeaud JM. Implication of Actin in the uptake of sucrose and valine in the tap root and leaf of sugar beet. Physiol Plant. 2021 Jan 9. doi: 10.1111/ppl.13322. Epub ahead of print. PMID: 33421161.

4: Wang CY, Chao YJ, Chen YL, Wang TW, Phan NN, Hsu HP, Shan YS, Lai MD. Upregulation of peroxisome proliferator-activated receptor-α and the lipid metabolism pathway promotes carcinogenesis of ampullary cancer. Int J Med Sci. 2021 Jan 1;18(1):256-269. doi: 10.7150/ijms.48123. PMID: 33390794; PMCID: PMC7738964.

5: Casarrubios L, Gómez-Cerezo N, Feito MJ, Vallet-Regí M, Arcos D, Portolés MT. Ipriflavone-Loaded Mesoporous Nanospheres with Potential Applications for Periodontal Treatment. Nanomaterials (Basel). 2020 Dec 21;10(12):2573. doi: 10.3390/nano10122573. PMID: 33371499; PMCID: PMC7767486.

6: Randelli F, Sartori P, Carlomagno C, Bedoni M, Menon A, Vezzoli E, Sommariva M, Gagliano N. The Collagen-Based Medical Device MD-Tissue Acts as a Mechanical Scaffold Influencing Morpho-Functional Properties of Cultured Human Tenocytes. Cells. 2020 Dec 8;9(12):2641. doi: 10.3390/cells9122641. PMID: 33302563; PMCID: PMC7763591.

7: Peng CC, Huang CY, Ahmed AF, Hwang TL, Sheu JH. Anti-Inflammatory Cembranoids from a Formosa Soft Coral Sarcophyton cherbonnieri. Mar Drugs. 2020 Nov 19;18(11):573. doi: 10.3390/md18110573. PMID: 33228224; PMCID: PMC7699541.

8: Takaishi K, Kinoshita H, Feng GG, Azma T, Kawahito S, Kitahata H. Cytoskeleton-disrupting agent cytochalasin B reduces oxidative stress caused by high glucose in the human arterial smooth muscle. J Pharmacol Sci. 2020 Dec;144(4):197-203. doi: 10.1016/j.jphs.2020.08.004. Epub 2020 Aug 23. PMID: 33070838.

9: Li SL, Wu HC, Hwang TL, Lin CH, Yang SS, Chang HS. Phytochemical Investigation and Anti-Inflammatory Activity of the Leaves of Machilus japonica var. kusanoi. Molecules. 2020 Sep 10;25(18):4149. doi: 10.3390/molecules25184149. PMID: 32927887; PMCID: PMC7570621.

10: Kobayashi M, Ito J, Shirasuna K, Kuwayama T, Iwata H. Comparative analysis of cell-free DNA content in culture medium and mitochondrial DNA copy number in porcine parthenogenetically activated embryos. J Reprod Dev. 2020 Dec 22;66(6):539-546. doi: 10.1262/jrd.2020-097. Epub 2020 Sep 8. PMID: 32908082; PMCID: PMC7768170.

11: de With SAJ, Man WH, Maas C, Ten Berg M, Cahn W, Koekman AC, van Solinge WW, Tak T. Neutrophil fluorescence in clozapine users is attributable to a 14kDa secretable protein. Pharmacol Res Perspect. 2020 Oct;8(5):e00627. doi: 10.1002/prp2.627. PMID: 32812697; PMCID: PMC7437349.

12: Gaul S, Leszczynska A, Alegre F, Kaufmann B, Johnson CD, Adams LA, Wree A, Damm G, Seehofer D, Calvente CJ, Povero D, Kisseleva T, Eguchi A, McGeough MD, Hoffman HM, Pelegrin P, Laufs U, Feldstein AE. Hepatocyte pyroptosis and release of inflammasome particles induce stellate cell activation and liver fibrosis. J Hepatol. 2021 Jan;74(1):156-167. doi: 10.1016/j.jhep.2020.07.041. Epub 2020 Aug 4. PMID: 32763266; PMCID: PMC7749849.

13: Sano A, Sano H, Iwanaga T, Tohda Y. Functional role of phosphatidylcholine- specific phospholipase C in regulating leukotriene synthesis and degranulation in human eosinophils. Eur J Pharmacol. 2020 Oct 5;884:173353. doi: 10.1016/j.ejphar.2020.173353. Epub 2020 Jul 22. PMID: 32707189.

14: Fu H, Liu B, Li L, Lemere CA. Microglia Do Not Take Up Soluble Amyloid-beta Peptides, But Partially Degrade Them by Secreting Insulin-degrading Enzyme. Neuroscience. 2020 Sep 1;443:30-43. doi: 10.1016/j.neuroscience.2020.07.020. Epub 2020 Jul 19. PMID: 32697980; PMCID: PMC7484427.

15: Hasegawa DK, Zhang P, Turnbull MW. Intracellular dynamics of polydnavirus innexin homologues. Insect Mol Biol. 2020 Oct;29(5):477-489. doi: 10.1111/imb.12657. Epub 2020 Aug 7. PMID: 32683761.

16: Gomzikova MO, Aimaletdinov AM, Bondar OV, Starostina IG, Gorshkova NV, Neustroeva OA, Kletukhina SK, Kurbangaleeva SV, Vorobev VV, Garanina EE, Persson JL, Jeyapalan J, Mongan NP, Khaiboullina SF, Rizvanov AA. Immunosuppressive properties of cytochalasin B-induced membrane vesicles of mesenchymal stem cells: comparing with extracellular vesicles derived from mesenchymal stem cells. Sci Rep. 2020 Jul 1;10(1):10740. doi: 10.1038/s41598-020-67563-9. PMID: 32612100; PMCID: PMC7330035.

17: Gomzikova MO, Kletukhina SK, Kurbangaleeva SV, Neustroeva OA, Vasileva OS, Garanina EE, Khaiboullina SF, Rizvanov AA. Mesenchymal Stem Cell Derived Biocompatible Membrane Vesicles Demonstrate Immunomodulatory Activity Inhibiting Activation and proliferation of Human Mononuclear Cells. Pharmaceutics. 2020 Jun 23;12(6):577. doi: 10.3390/pharmaceutics12060577. PMID: 32585863; PMCID: PMC7356506.