CJ-15161 hydrochloride

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MedKoo CAT#: 412983

CAS#: 204970-99-0 (HCl)

Description: CJ-15161 hydrochloride is the salt form of CJ-15161 (free base), an opioid κ-receptor agonist, is undergoing development with Pfizer as an analgesic agent.

Chemical Structure

CJ-15161 hydrochloride
CAS# 204970-99-0 (HCl)

Theoretical Analysis

MedKoo Cat#: 412983
Name: CJ-15161 hydrochloride
CAS#: 204970-99-0 (HCl)
Chemical Formula: C23H32ClN3O2
Exact Mass: 0.00
Molecular Weight: 417.978
Elemental Analysis: C, 66.09; H, 7.72; Cl, 8.48; N, 10.05; O, 7.66

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Related CAS #: 204970-99-0 (HCl)   204970-97-8 (free base)  

Synonym: CJ-15161 hydrochloride; CJ15161 hydrochloride; CJ 15161 hydrochloride

IUPAC/Chemical Name: Benzamide, 4-(((1S)-2-((3S)-3-hydroxy-1-pyrrolidinyl)-1-phenylethyl)methylamino)-N-propyl-, hydrochloride (1:1)


InChi Code: InChI=1S/C23H31N3O2.ClH/c1-3-14-24-23(28)19-9-11-20(12-10-19)25(2)22(18-7-5-4-6-8-18)17-26-15-13-21(27)16-26;/h4-12,21-22,27H,3,13-17H2,1-2H3,(H,24,28);1H/t21-,22+;/m0./s1

SMILES Code: O=C(NCCC)C1=CC=C(N([C@@H](C2=CC=CC=C2)CN3C[C@@H](O)CC3)C)C=C1.[H]Cl

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 417.98 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Ghosh A, Sieser JE, Caron S, Couturier M, Dupont-Gaudet K, Girardin M. Cu- catalyzed N-arylation of oxazolidinones: an efficient synthesis of the kappa- opioid receptor Agonist CJ-15161. J Org Chem. 2006 Feb 3;71(3):1258-61. doi: 10.1021/jo052060z. PMID: 16438550.

2: Ghosh A, Sieser JE, Caron S, Watson TJ. Synthesis of the kappa-agonist CJ-15,161 via a palladium-catalyzed cross-coupling reaction. Chem Commun (Camb). 2002 Aug 7;(15):1644-5. doi: 10.1039/b204844b. PMID: 12170823.