Americanin A

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 463821

CAS#: 69506-79-2

Description: Americanin A natural thrombin inhibitor, suppressing melanin synthesis, regulating the ATM/ATR signaling pathway and the Skp2-p27 axis in human colon cancer cells.

Chemical Structure

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Americanin A
CAS# 69506-79-2
Instruction

Theoretical Analysis

MedKoo Cat#: 463821
Name: Americanin A
CAS#: 69506-79-2
Chemical Formula: C18H16O6
Exact Mass: 328.09
Molecular Weight: 328.320
Elemental Analysis: C, 65.85; H, 4.91; O, 29.24

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: Americanin A; Americanin-A;

IUPAC/Chemical Name: (E)-3-((2S,3S)-2-(3,4-dihydroxyphenyl)-3-(hydroxymethyl)-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)acrylaldehyde

InChi Key: NTXXGPYGMQQSML-QLJMBOKNSA-N

InChi Code: InChI=1S/C18H16O6/c19-7-1-2-11-3-6-15-16(8-11)23-17(10-20)18(24-15)12-4-5-13(21)14(22)9-12/h1-9,17-18,20-22H,10H2/b2-1+/t17-,18-/m0/s1

SMILES Code: O=C/C=C/C1=CC=C(O[C@@H](C2=CC=C(O)C(O)=C2)[C@H](CO)O3)C3=C1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 328.32 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: De La Cruz-Sánchez NG, Gómez-Rivera A, Alvarez-Fitz P, Ventura-Zapata E, Pérez-García MD, Avilés-Flores M, Gutiérrez-Román AS, González-Cortazar M. Antibacterial activity of Morinda citrifolia Linneo seeds against Methicillin- Resistant Staphylococcus spp. Microb Pathog. 2019 Mar;128:347-353. doi: 10.1016/j.micpath.2019.01.030. Epub 2019 Jan 23. PMID: 30682527.

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3: Jung C, Hong JY, Bae SY, Kang SS, Park HJ, Lee SK. Antitumor Activity of Americanin A Isolated from the Seeds of Phytolacca americana by Regulating the ATM/ATR Signaling Pathway and the Skp2-p27 Axis in Human Colon Cancer Cells. J Nat Prod. 2015 Dec 24;78(12):2983-93. doi: 10.1021/acs.jnatprod.5b00743. Epub 2015 Nov 23. PMID: 26595875.

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15: Fukuyama Y, Hasegawa T, Toda M, Kodama M, Okazaki H. Structures of americanol A and isoamericanol A having a neurotrophic property from the seeds of Phytolacca americana. Chem Pharm Bull (Tokyo). 1992 Jan;40(1):252-4. doi: 10.1248/cpb.40.252. PMID: 1576680.

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