WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 463810
CAS#: unknown
Description: PZ-1444 is a novel inverse agonist of 5-HT6 receptor.
MedKoo Cat#: 463810
Name: PZ-1444
CAS#: unknown
Chemical Formula: C19H22FN5
Exact Mass: 339.1859
Molecular Weight: 339.4184
Elemental Analysis: C, 67.24; H, 6.53; F, 5.60; N, 20.63
This product is not in stock, which may be available by custom synthesis.
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Synonym: PZ-1444; PZ 1444; PZ1444;
IUPAC/Chemical Name: 2-ethyl-3-(3-fluorobenzyl)-7-(piperazin-1-yl)-3H-imidazo[4,5-b]pyridine
InChi Key: VVFMFUGAHRAYJX-UHFFFAOYSA-N
InChi Code: InChI=1S/C19H22FN5/c1-2-17-23-18-16(24-10-8-21-9-11-24)6-7-22-19(18)25(17)13-14-4-3-5-15(20)12-14/h3-7,12,21H,2,8-11,13H2,1H3
SMILES Code: FC1=CC(CN2C(CC)=NC3=C(N4CCNCC4)C=CN=C32)=CC=C1
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 339.4184 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Vanda D, Canale V, Chaumont-Dubel S, Kurczab R, Satała G, Koczurkiewicz- Adamczyk P, Krawczyk M, Pietruś W, Blicharz K, Pękala E, Bojarski AJ, Popik P, Marin P, Soural M, Zajdel P. Imidazopyridine-Based 5-HT6 Receptor Neutral Antagonists: Impact of N1-Benzyl and N1-Phenylsulfonyl Fragments on Different Receptor Conformational States. J Med Chem. 2021 Jan 13. doi: 10.1021/acs.jmedchem.0c02009. Epub ahead of print. PMID: 33439019.
