7-Xylosyltaxol
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MedKoo CAT#: 463775

CAS#: 90332-66-4

Description: 7-Xylosyltaxol is a taxane and derivative of paclitaxel that has been found in T. chinensis and has microtubule disruptor and anticancer activities. It induces the disassembly of pig brain and Physarum microtubules in cell-free assays. 7-Xylosyltaxol inhibits proliferation of A549, MCF-7, A2780, HCT-8, and SW480 cancer cells with IC50 values of 0.39, 0.16, 0.85, 5.9, and 5.6 µM, respectively.


Chemical Structure

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7-Xylosyltaxol
CAS# 90332-66-4

Theoretical Analysis

MedKoo Cat#: 463775
Name: 7-Xylosyltaxol
CAS#: 90332-66-4
Chemical Formula: C52H59NO18
Exact Mass: 985.3732
Molecular Weight: 986.033
Elemental Analysis: C, 63.34; H, 6.03; N, 1.42; O, 29.21

Price and Availability

Size Price Availability Quantity
1.0mg USD 430.0 2 Weeks
5.0mg USD 910.0 2 Weeks
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Synonym: 7-Xylosyltaxol; 7 Xylosyltaxol;

IUPAC/Chemical Name: (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-9-(((2R,3S)-3-benzamido-2-hydroxy-3-phenylpropanoyl)oxy)-12-(benzoyloxy)-11-hydroxy-4a,8,13,13-tetramethyl-5-oxo-4-(((2S,3R,4S,5R)-3,4,5-trihydroxytetrahydro-2H-pyran-2-yl)oxy)-3,4,4a,5,6,9,10,11,12,12a-decahydro-1H-7,11-methanocyclodeca[3,4]benzo[1,2-b]oxete-6,12b(2aH)-diyl diacetate

InChi Key: ZVEGOBHUZTXSFK-TZIKQHFSSA-N

InChi Code: InChI=1S/C52H59NO18/c1-26-33(68-47(63)39(58)37(29-16-10-7-11-17-29)53-45(61)30-18-12-8-13-19-30)23-52(64)44(70-46(62)31-20-14-9-15-21-31)42-50(6,43(60)41(67-27(2)54)36(26)49(52,4)5)34(22-35-51(42,25-66-35)71-28(3)55)69-48-40(59)38(57)32(56)24-65-48/h7-21,32-35,37-42,44,48,56-59,64H,22-25H2,1-6H3,(H,53,61)/t32-,33+,34+,35-,37+,38+,39-,40-,41-,42+,44+,48+,50-,51+,52-/m1/s1

SMILES Code: C[C@@]1([C@@]([H])([C@@](CO2)(OC(C)=O)[C@]2(C[C@@H]1O[C@@]([H])([C@H](O)[C@H]3O)OC[C@H]3O)[H])[C@@H]4OC(C5=CC=CC=C5)=O)C([C@H](OC(C)=O)C6=C([C@H](C[C@@]4(C6(C)C)O)OC([C@@H]([C@@H](NC(C7=CC=CC=C7)=O)C8=CC=CC=C8)O)=O)C)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 986.033 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Yusakul G, Sakamoto S, Tanaka H, Morimoto S. Efficient expression of single chain variable fragment antibody against paclitaxel using the Bombyx mori nucleopolyhedrovirus bacmid DNA system and its characterizations. J Nat Med. 2016 Jul;70(3):592-601. doi: 10.1007/s11418-016-0981-5. Epub 2016 Mar 3. PMID: 26940321.

2: Yu SS, Sun QW, Zhang XP, Tian SN, Bo PL. [Content and distribution of active components in cultivated and wild Taxus chinensis var. mairei plants]. Ying Yong Sheng Tai Xue Bao. 2012 Oct;23(10):2641-7. Chinese. PMID: 23359921.

3: Chao Z, Tan M, Paudel MK, Sakamoto S, Ma L, Sasaki-Tabata K, Tanaka H, Shoyama Y, Xuan L, Morimoto S. Development of an indirect competitive enzyme- linked immunosorbent assay (icELISA) using highly specific monoclonal antibody against paclitaxel. J Nat Med. 2013 Jul;67(3):512-8. doi: 10.1007/s11418-012-0708-1. Epub 2012 Sep 25. PMID: 23007175.