Azoffluxin

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 463725

CAS#: unknown

Description: Azoffluxin is a novel oxindole efflux inhibitor, enhancing azole efficacy in a Cdr1-dependent manner, being active against diverse C. auris strains, displaying activity against azole-resistant C. albicans.

Chemical Structure

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Azoffluxin
CAS# unknown
Instruction

Theoretical Analysis

MedKoo Cat#: 463725
Name: Azoffluxin
CAS#: unknown
Chemical Formula: C34H34FNO9
Exact Mass: 619.22
Molecular Weight: 619.642
Elemental Analysis: C, 65.90; H, 5.53; F, 3.07; N, 2.26; O, 23.24

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: Azoffluxin; CMLD012336; CMLD 012336 CMLD-012336;

IUPAC/Chemical Name: 6-fluoro-3,3-bis(6-(((R)-2-hydroxy-4-methylpent-4-en-1-yl)oxy)benzo[d][1,3]dioxol-5-yl)indolin-2-one

InChi Key: AORMGRZYXMMKLB-FGZHOGPDSA-N

InChi Code: InChI=1S/C34H34FNO9/c1-18(2)7-21(37)14-40-27-12-31-29(42-16-44-31)10-24(27)34(23-6-5-20(35)9-26(23)36-33(34)39)25-11-30-32(45-17-43-30)13-28(25)41-15-22(38)8-19(3)4/h5-6,9-13,21-22,37-38H,1,3,7-8,14-17H2,2,4H3,(H,36,39)/t21-,22-/m1/s1

SMILES Code: O=C1NC2=C(C=CC(F)=C2)C1(C3=C(OC[C@H](O)CC(C)=C)C=C(OCO4)C4=C3)C5=C(OC[C@H](O)CC(C)=C)C=C(OCO6)C6=C5

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 619.64 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Iyer KR, Camara K, Daniel-Ivad M, Trilles R, Pimentel-Elardo SM, Fossen JL, Marchillo K, Liu Z, Singh S, Muñoz JF, Kim SH, Porco JA Jr, Cuomo CA, Williams NS, Ibrahim AS, Edwards JE Jr, Andes DR, Nodwell JR, Brown LE, Whitesell L, Robbins N, Cowen LE. An oxindole efflux inhibitor potentiates azoles and impairs virulence in the fungal pathogen Candida auris. Nat Commun. 2020 Dec 22;11(1):6429. doi: 10.1038/s41467-020-20183-3. PMID: 33353950.