WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 463716

CAS#: 19220-35-0

Description: Osteoprotegerin is a soluble secreted member of the tumor necrosis factor receptor superfamily, inhibiting osteoclastogenesis by interrupting the signaling between stromal cells and osteoclastic progenitor cells, leading to excess accumulation of bone and cartilage.

Chemical Structure

CAS# 19220-35-0

Theoretical Analysis

MedKoo Cat#: 463716
Name: Osteoprotegerin
CAS#: 19220-35-0
Chemical Formula: C18H32O2
Exact Mass: 280.2402
Molecular Weight: 280.452
Elemental Analysis: C, 77.09; H, 11.50; O, 11.41

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: Osteoprotegerin; OPG; Tnfrsf11b; Tnfrsf 11b; Tnfrsf-11b; Tumor Necrosis Factor Receptor 11b;

IUPAC/Chemical Name: octadec-7-ynoic acid


InChi Code: InChI=1S/C18H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h2-10,13-17H2,1H3,(H,19,20)


Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 280.452 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Payr S, Rosado-Balmayor E, Tiefenboeck T, Schuseil T, Unger M, Seeliger C, van Griensven M. Direct comparison of 3D and 2D cultivation reveals higher osteogenic capacity of elderly osteoblasts in 3D. J Orthop Surg Res. 2021 Jan 6;16(1):13. doi: 10.1186/s13018-020-02153-z. PMID: 33407623.

2: Tamashunas AC, Katiyar A, Zhang Q, Purkayastha P, Singh PK, Chukkapalli SS, Lele TP. Osteoprotegerin is sensitive to actomyosin tension in human periodontal ligament fibroblasts. J Cell Physiol. 2021 Jan 5. doi: 10.1002/jcp.30256. Epub ahead of print. PMID: 33400284.

3: Torquato LC, Suárez EAC, Bernardo DV, Pinto ILR, Mantovani LO, Silva TIL, Jardini MAN, Santamaria MP, De Marco AC. Bone repair assessment of critical size defects in rats treated with mineralized bovine bone (Bio-Oss®) and photobiomodulation therapy: a histomorphometric and immunohistochemical study. Lasers Med Sci. 2021 Jan 5. doi: 10.1007/s10103-020-03234-5. Epub ahead of print. PMID: 33400010.

4: Ochoa-Précoma R, Pacheco-Soto BT, Porchia LM, Torres-Rasgado E, Pérez-Fuentes R, Gonzalez-Mejia ME. Association between Osteoprotegerin and Charcot Neuroarthropathy: a systematic review. Acta Diabetol. 2021 Jan 4. doi: 10.1007/s00592-020-01638-x. Epub ahead of print. PMID: 33394132.

5: Yang C, Gu Z, Ding R, Huang C, Li Q, Xie D, Zhang R, Qiu Y. Long non-coding RNA MEG3 silencing and microRNA-214 restoration elevate osteoprotegerin expression to ameliorate osteoporosis by limiting TXNIP. J Cell Mol Med. 2021 Jan 3. doi: 10.1111/jcmm.16096. Epub ahead of print. PMID: 33393160.

6: Yasuda H. Discovery of the RANKL/RANK/OPG system. J Bone Miner Metab. 2021 Jan 3. doi: 10.1007/s00774-020-01175-1. Epub ahead of print. PMID: 33389131.

7: Kao SY, Katsumi S, Han D, Bizaki-Vallaskangas AJ, Vasilijic S, Landegger LD, Kristiansen AG, McKenna MJ, Stankovic KM. Postnatal Expression and Possible Function of RANK and RANKL in the Murine Inner Ear. Bone. 2020 Dec 29:115837. doi: 10.1016/j.bone.2020.115837. Epub ahead of print. PMID: 33385614.

8: Zhu S, Häussling V, Aspera-Werz RH, Chen T, Braun B, Weng W, Histing T, Nussler AK. Bisphosphonates Reduce Smoking-Induced Osteoporotic-Like Alterations by Regulating RANKL/OPG in an Osteoblast and Osteoclast Co-Culture Model. Int J Mol Sci. 2020 Dec 23;22(1):E53. doi: 10.3390/ijms22010053. PMID: 33374546.

9: Carrillo-López N, Martínez-Arias L, Alonso-Montes C, Martín-Carro B, Martín- Vírgala J, Ruiz-Ortega M, Fernández-Martín JL, Dusso AS, Rodriguez-García M, Naves-Díaz M, Cannata-Andía JB, Panizo S. The receptor activator of nuclear factor κΒ ligand receptor leucine-rich repeat-containing G-protein-coupled receptor 4 contributes to parathyroid hormone-induced vascular calcification. Nephrol Dial Transplant. 2020 Dec 26:gfaa290. doi: 10.1093/ndt/gfaa290. Epub ahead of print. PMID: 33367746.

10: Sukul M, Sahariah P, Lauzon HL, Borges J, Másson M, Mano JF, Haugen HJ, Reseland JE. In vitro biological response of human osteoblasts in 3D chitosan sponges with controlled degree of deacetylation and molecular weight. Carbohydr Polym. 2021 Feb 15;254:117434. doi: 10.1016/j.carbpol.2020.117434. Epub 2020 Nov 22. PMID: 33357907.

11: Gómez-Vaquero C, Martín I, Zacarías A, Alía P, Loza E, Carmona L, Narváez J. Relation of the Serum Levels of DKK-1 and Osteoprotegerin with Bone Mass in Tightly Controlled Rheumatoid Arthritis. Curr Rheumatol Rev. 2020 Dec 20. doi: 10.2174/1573397116666201221112509. Epub ahead of print. PMID: 33349216.

12: Wehner C, Behm C, Husejnagic S, Moritz A, Rausch-Fan X, Andrukhov O. Effect of Multi-Phosphonate Coating of Titanium Surfaces on Osteogenic Potential. Materials (Basel). 2020 Dec 17;13(24):5777. doi: 10.3390/ma13245777. PMID: 33348895; PMCID: PMC7766650.

13: Tomaszewska E, Świątkiewicz S, Arczewska-Włosek A, Wojtysiak D, Dobrowolski P, Domaradzki P, Świetlicka I, Donaldson J, Hułas-Stasiak M, Muszyński S. Alpha- Ketoglutarate: An Effective Feed Supplement in Improving Bone Metabolism and Muscle Quality of Laying Hens: A Preliminary Study. Animals (Basel). 2020 Dec 17;10(12):2420. doi: 10.3390/ani10122420. PMID: 33348724; PMCID: PMC7767309.

14: Gupta A, Singh N, Kumar A, Verma UP, Verma AK, Shyam H, Lal N, Kant S, Kumari A. Differential expression of inflammatory responsive genes between chronic periodontitis and periodontally affected bronchiectasis patients. Mol Biol Res Commun. 2020 Dec;9(4):169-172. doi: 10.22099/mbrc.2020.37397.1508. PMID: 33344663; PMCID: PMC7731971.

15: Huang SJ, Wang HW, Wu HF, Wei QY, Luo S, Xu L, Guan HQ. Osteoprotegerin, interleukin and hepatocyte growth factor for prediction of diabetes and hypertension in the third trimester of pregnancy. World J Clin Cases. 2020 Nov 26;8(22):5529-5534. doi: 10.12998/wjcc.v8.i22.5529. PMID: 33344543; PMCID: PMC7716305.

16: Ma H, Wang X, Zhang W, Li H, Zhao W, Sun J, Yang M. Melatonin Suppresses Ferroptosis Induced by High Glucose via Activation of the Nrf2/HO-1 Signaling Pathway in Type 2 Diabetic Osteoporosis. Oxid Med Cell Longev. 2020 Dec 4;2020:9067610. doi: 10.1155/2020/9067610. PMID: 33343809; PMCID: PMC7732386.

17: Migacz M, Janoska-Gawrońska A, Holecki M, Chudek J. The role of osteoprotegerin in the development, progression and management of abdominal aortic aneurysms. Open Med (Wars). 2020 May 26;15(1):457-463. doi: 10.1515/med-2020-0046. PMID: 33336003; PMCID: PMC7712403.

18: Glasnović A, O'Mara N, Kovačić N, Grčević D, Gajović S. RANK/RANKL/OPG Signaling in the Brain: A Systematic Review of the Literature. Front Neurol. 2020 Nov 19;11:590480. doi: 10.3389/fneur.2020.590480. PMID: 33329338; PMCID: PMC7710989.

19: Pihlstrøm HK, Ueland T, Michelsen AE, Aukrust P, Gatti F, Hammarström C, Kasprzycka M, Wang J, Haraldsen G, Mjøen G, Dahle DO, Midtvedt K, Eide IA, Hartmann A, Holdaas H. Exploring the potential effect of paricalcitol on markers of inflammation in de novo renal transplant recipients. PLoS One. 2020 Dec 16;15(12):e0243759. doi: 10.1371/journal.pone.0243759. PMID: 33326471; PMCID: PMC7743930.

20: Zhang C, Zhu J, Jia J, Guan Z, Sun T, Zhang W, Yuan W, Wang H, Leng H, Song C. Once-weekly parathyroid hormone combined with ongoing long-term alendronate treatment promotes osteoporotic fracture healing in ovariectomized rats. J Orthop Res. 2020 Dec 16. doi: 10.1002/jor.24953. Epub ahead of print. PMID: 33325546.