WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 412849
CAS#: 77146-42-0 (phosphanilate)
Description: Chlorhexidine phosphanilate is an antibacterial used for prophylactic treatment of burns.
MedKoo Cat#: 412849
Name: Chlorhexidine phosphanilate
CAS#: 77146-42-0 (phosphanilate)
Chemical Formula: C34H46Cl2N12O6P2
Exact Mass: 850.2516
Molecular Weight: 851.67
Elemental Analysis: C, 47.95; H, 5.44; Cl, 8.32; N, 19.74; O, 11.27; P, 7.27
This product is not in stock, which may be available by custom synthesis.
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Related CAS #: 77146-42-0 (phosphanilate) 3697-42-5 (HCl) 18472-51-0 (gluconate) 55-56-1 (free base)
Synonym: Chlorhexidine phosphanilate; WP973; WP-973; WP 973
IUPAC/Chemical Name: 2,4,11,13-Tetraazatetradecanediimidamide, N,N''-bis(4-chlorophenyl)-3,12-diimino-, (4-aminophenyl)phosphonate (1:2)
InChi Key: NSCOCGOFKMUTMW-UHFFFAOYSA-N
InChi Code: InChI=1S/C22H30Cl2N10.2C6H8NO3P/c23-15-5-9-17(10-6-15)31-21(27)33-19(25)29-13-3-1-2-4-14-30-20(26)34-22(28)32-18-11-7-16(24)8-12-18;2*7-5-1-3-6(4-2-5)11(8,9)10/h5-12H,1-4,13-14H2,(H5,25,27,29,31,33)(H5,26,28,30,32,34);2*1-4H,7H2,(H2,8,9,10)
SMILES Code: N=C(NC1=CC=C(Cl)C=C1)NC(NCCCCCCNC(NC(NC2=CC=C(Cl)C=C2)=N)=N)=N.NC3=CC=C(P(O)(O)=O)C=C3.NC4=CC=C(P(O)(O)=O)C=C4
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 851.67 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Wang JC, Williams RR, Wang L, Loder J. In vitro skin permeation and bioassay of chlorhexidine phosphanilate, a new antimicrobial agent. Pharm Res. 1990 Oct;7(10):995-1002. doi: 10.1023/a:1015978714186. PMID: 2281046.
2: Miller LM, Loder JS, Hansbrough JF, Peterson HD, Monafo WW, Jordan MH. Patient tolerance study of topical chlorhexidine diphosphanilate: a new topical agent for burns. Burns. 1990 Jun;16(3):217-20. doi: 10.1016/0305-4179(90)90044-w. PMID: 2383364.
3: Loder JS, Krochmal L. Topical chlorhexidine phosphanilate for prophylactic treatment of burns. N Engl J Med. 1986 May 8;314(19):1256-7. PMID: 3702924.
4: Gadde RR, McNiff EF, Peer MM. High-performance liquid chromatographic analysis of chlorhexidine phosphanilate, a new antimicrobial agent. J Pharm Biomed Anal. 1991;9(10-12):1031-6. doi: 10.1016/0731-7085(91)80040-g. PMID: 1822169.
