Iodoxamate Meglumine

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 412844

CAS#: 51764-33-1

Description: Iodoxamate Meglumine is a Diagnostic Aid (Radiopaque Medium)


Chemical Structure

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Iodoxamate Meglumine
CAS# 51764-33-1

Theoretical Analysis

MedKoo Cat#: 412844
Name: Iodoxamate Meglumine
CAS#: 51764-33-1
Chemical Formula: C40H60I6N4O20
Exact Mass: 1,677.81
Molecular Weight: 1,678.350
Elemental Analysis: C, 28.63; H, 3.60; I, 45.37; N, 3.34; O, 19.07

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: Iodoxamate Meglumine; Endobil; EINECS 257-398-6

IUPAC/Chemical Name: Benzoic acid, 3,3'-((1,16-dioxo-4,7,10,13-tetraoxahexadecane-1,16-diyl)diimino)bis(2,4,6-triiodo-, compound with 1-deoxy-1-(methylamino)-D-glucitol (1:2)

InChi Key: LNBGFESBSAEKAE-VRWDCWMNSA-N

InChi Code: InChI=1S/C26H26I6N2O10.2C7H17NO5/c27-13-11-15(29)23(21(31)19(13)25(37)38)33-17(35)1-3-41-5-7-43-9-10-44-8-6-42-4-2-18(36)34-24-16(30)12-14(28)20(22(24)32)26(39)40;2*1-8-2-4(10)6(12)7(13)5(11)3-9/h11-12H,1-10H2,(H,33,35)(H,34,36)(H,37,38)(H,39,40);2*4-13H,2-3H2,1H3/t;2*4-,5+,6+,7+/m.00/s1

SMILES Code: O=C(NC1=C(I)C(C(O)=O)=C(I)C=C1I)CCOCCOCCOCCOCCC(NC2=C(I)C(C(O)=O)=C(I)C=C2I)=O.O[C@H]([C@H]([C@@H]([C@@H](CO)O)O)O)CNC.O[C@H]([C@H]([C@@H]([C@@H](CO)O)O)O)CNC

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 1,678.35 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Taenzer V, Volkhardt V. Double blind comparison of meglumine iotroxate (Biliscopin), meglumine iodoxamate (Endobil), and meglumine ioglycamate (Biligram). AJR Am J Roentgenol. 1979 Jan;132(1):55-8. doi: 10.2214/ajr.132.1.55. PMID: 103404.

2: Wallers KJ, McDermott P, James WB. Intravenous cholangiography by bolus injection of meglumine iotroxamate and meglumine iodoxamate: a comparative trial of two new contrast media. Clin Radiol. 1981 Jul;32(4):457-9. doi: 10.1016/s0009-9260(81)80304-2. PMID: 6894722.

3: Swanson DP, Dick TJ, Simms SM, Thrall JH. Product selection criteria for intravascular ionic contrast media. Clin Pharm. 1985 Sep-Oct;4(5):527-38. PMID: 3902331.

4: Dohmen JP, Lemmens JA, Lamers JJ. A double-blind comparison of meglumine iotroxate (Biliscopin) and meglumine iodoxamate (Cholovue). Diagn Imaging. 1981;50(6):305-8. PMID: 7035108.

5: Robbins AH, Sargent EN, Vincent ME, Boswell W, Meyers HI. Double-blind comparison of meglumine lodoxamate (Cholovue) and meglumine iodipamide (Cholografin). AJR Am J Roentgenol. 1976 Aug;127(2):257-60. doi: 10.2214/ajr.127.2.257. PMID: 182003.

6: Robbins AH, Earampamoorthy S, Koff RS, Di Fazio LT, Wickis EA, Gertler AN. Successful intravenous cholecystocholangiography in the jaundiced patient using meglumine iodoxamate (Cholovue). AJR Am J Roentgenol. 1976 Jan;126(1):70-6. doi: 10.2214/ajr.126.1.70. PMID: 175687.

7: Nilsson U. Adverse reactions to iotroxate at intravenous cholangiography. A prospective clinical investigation and review of the literature. Acta Radiol. 1987 Sep-Oct;28(5):571-5. PMID: 2960350.

8: Zaunbauer W, Grandjean EM, Paumgartner G, Fuchs WA. Die Kinetik der biliären Ausscheidung der Gallekontrastmittel Ioglycamid, Iodoxamat und Iotroxamat beim Hund [Biliary excretion kinetics of the biliary contrast media ioglycamide, iodoxamate and iotroxamate in the dog]. Schweiz Med Wochenschr. 1981 Jan 31;111(5):157-61. German. PMID: 6895123.

9: Fumino S, Ono S, Kimura O, Deguchi E, Iwai N. Diagnostic impact of computed tomography cholangiography and magnetic resonance cholangiopancreatography on pancreaticobiliary maljunction. J Pediatr Surg. 2011 Jul;46(7):1373-8. doi: 10.1016/j.jpedsurg.2011.01.026. PMID: 21763837.

10: Fleischmann D, Ringl H, Schöfl R, Pötzi R, Kontrus M, Henk C, Bankier AA, Kettenbach J, Mostbeck GH. Three-dimensional spiral CT cholangiography in patients with suspected obstructive biliary disease: comparison with endoscopic retrograde cholangiography. Radiology. 1996 Mar;198(3):861-8. doi: 10.1148/radiology.198.3.8628884. PMID: 8628884.