WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 463705
CAS#: 748136-54-1
Description: OSIP339391 is a A2BAR antagonist.
MedKoo Cat#: 463705
Name: OSIP339391
CAS#: 748136-54-1
Chemical Formula: C30H35N7O2
Exact Mass: 525.2852
Molecular Weight: 525.657
Elemental Analysis: C, 68.55; H, 6.71; N, 18.65; O, 6.09
This product is not in stock, which may be available by custom synthesis.
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Synonym: OSIP339391; OSIP 339391; OSIP-339391; UCS15A; UCS 15A; UCS-15A;
IUPAC/Chemical Name: N-(2-((2-phenyl-6-(4-(3-phenylpropyl)piperazine-1-carbonyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)ethyl)acetamide
InChi Key: MIUCZFWBCFZKEU-UHFFFAOYSA-N
InChi Code: InChI=1S/C30H35N7O2/c1-22(38)31-14-15-32-28-25-21-26(33-29(25)35-27(34-28)24-12-6-3-7-13-24)30(39)37-19-17-36(18-20-37)16-8-11-23-9-4-2-5-10-23/h2-7,9-10,12-13,21H,8,11,14-20H2,1H3,(H,31,38)(H2,32,33,34,35)
SMILES Code: CC(NCCNC1=C2C(NC(C(N3CCN(CCCC4=CC=CC=C4)CC3)=O)=C2)=NC(C5=CC=CC=C5)=N1)=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 525.657 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Ortore G, Martinelli A. A2B receptor ligands: past, present and future trends. Curr Top Med Chem. 2010;10(9):923-40. doi: 10.2174/156802610791268747. PMID: 20370659.
2: Kalla RV, Zablocki J, Tabrizi MA, Baraldi PG. Recent developments in A2B adenosine receptor ligands. Handb Exp Pharmacol. 2009;(193):99-122. doi: 10.1007/978-3-540-89615-9_4. PMID: 19639280.
3: Stewart M, Steinig AG, Ma C, Song JP, McKibben B, Castelhano AL, MacLennan SJ. [3H]OSIP339391, a selective, novel, and high affinity antagonist radioligand for adenosine A2B receptors. Biochem Pharmacol. 2004 Jul 15;68(2):305-12. doi: 10.1016/j.bcp.2004.03.026. PMID: 15194002.
4: Beukers MW, Meurs I, Ijzerman AP. Structure-affinity relationships of adenosine A2B receptor ligands. Med Res Rev. 2006 Sep;26(5):667-98. doi: 10.1002/med.20069. PMID: 16847822.
5: Mansourian M, Madadkar-Sobhani A, Mahnam K, Fassihi A, Saghaie L. Characterization of adenosine receptor in its native environment: insights from molecular dynamics simulations of palmitoylated/glycosylated, membrane- integrated human A(2B) adenosine receptor. J Mol Model. 2012 Sep;18(9):4309-24. doi: 10.1007/s00894-012-1427-y. Epub 2012 May 9. PMID: 22570080.
6: Gessi S, Varani K, Merighi S, Leung E, Mac Lennan S, Baraldi PG, Borea PA. Novel selective antagonist radioligands for the pharmacological study of A(2B) adenosine receptors. Purinergic Signal. 2006 Nov;2(4):583-8. doi: 10.1007/s11302-006-9019-x. Epub 2006 Jul 8. PMID: 18404460; PMCID: PMC2096665.
