WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 463684

CAS#: unknown

Description: M5049 is a novel potent and selective TLR7/8 inhibitor for treatment of autoimmunity.

Chemical Structure

CAS# unknown

Theoretical Analysis

MedKoo Cat#: 463684
Name: M5049
CAS#: unknown
Chemical Formula: C16H15F3N4
Exact Mass: 320.1249
Molecular Weight: 320.3192
Elemental Analysis: C, 60.00; H, 4.72; F, 17.79; N, 17.49

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: M5049; M 5049; M-5049;

IUPAC/Chemical Name: 5-((3S,5R)-3-amino-5-(trifluoromethyl)piperidin-1-yl)quinoline-8-carbonitrile


InChi Code: InChI=1S/C16H15F3N4/c17-16(18,19)11-6-12(21)9-23(8-11)14-4-3-10(7-20)15-13(14)2-1-5-22-15/h1-5,11-12H,6,8-9,21H2/t11-,12+/m1/s1

SMILES Code: N#CC1=C2N=CC=CC2=C(N3C[C@@H](N)C[C@@H](C(F)(F)F)C3)C=C1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 320.3192 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Vlach J, Bender AT, Przetak M, Pereira A, Deshpande A, Johnson T, Reissig S, Tzvetkov E, Musil D, Tahmassian-Morse N, Haselmayer P, Favre-Zimmerli S, Okitsu SL, Walsky RL, Sherer B. Discovery of M5049: A Novel Selective TLR7/8 Inhibitor for Treatment of Autoimmunity. J Pharmacol Exp Ther. 2020 Dec 16:JPET- AR-2020-000275. doi: 10.1124/jpet.120.000275. Epub ahead of print. PMID: 33328334.

2: Modell SM, Fleming PJ, Lopez WD, Goltz HH. Work in Progress: Immigrant Health Care from the Vantage of Cancer Testing and Screening. J Immigr Minor Health. 2020 Nov 24. doi: 10.1007/s10903-020-01129-9. Epub ahead of print. PMID: 33231790.

3: Modell SM, Kardia SLR. Religion as a Health Promoter During the 2019/2020 COVID Outbreak: View from Detroit. J Relig Health. 2020 Oct;59(5):2243-2255. doi: 10.1007/s10943-020-01052-1. PMID: 32548832; PMCID: PMC7297133.