BMS-P5 free base

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 555900

CAS#: 1550371-22-6 (free base)

Description: BMS-P5 is a Novel Peptidylarginine Deiminase 4 (PAD4) Inhibitor with pIC50 values in the range of 5-​7.5. BMS-P5 Blocks Formation of Neutrophil Extracellular Traps and Delays Progression of Multiple Myeloma. Administration of BMS-P5 to multiple myeloma-bearing mice delays appearance of symptoms and disease progression Targeting PAD4 may be beneficial for treatment of multiple myeloma.

Chemical Structure

BMS-P5 free base
CAS# 1550371-22-6 (free base)

Theoretical Analysis

MedKoo Cat#: 555900
Name: BMS-P5 free base
CAS#: 1550371-22-6 (free base)
Chemical Formula: C27H32N6O2
Exact Mass: 472.2587
Molecular Weight: 472.593
Elemental Analysis: C, 68.62; H, 6.83; N, 17.78; O, 6.77

Size Price Shipping out time Quantity
10mg USD 350 2 Weeks
25mg USD 550 2 Weeks
50mg USD 850 2 Weeks
100mg USD 1450 2 Weeks
200mg USD 1950 2 Weeks
500mg USD 3050 2 Weeks
1g USD 4850 2 Weeks
2g USD 7850 2 Weeks
Inquire bulk and customized quantity

Pricing updated 2021-02-28. Prices are subject to change without notice.

BMS-P5 free base is in stock.

Related CAS #: 1549811-36-0 (HCl)   1550371-22-6 (free base)    

Synonym: BMS-P5 free base; BMS-P5; BMSP5; BMS P5;

IUPAC/Chemical Name: ((2S,5R)-5-amino-2-methylpiperidin-1-yl)(2-(1-(cyclopropylmethyl)-1H-pyrrolo[2,3-b]pyridin-2-yl)-7-methoxy-1-methyl-1H-benzo[d]imidazol-5-yl)methanone


InChi Code: InChI=1S/C27H32N6O2/c1-16-6-9-20(28)15-32(16)27(34)19-11-21-24(23(13-19)35-3)31(2)26(30-21)22-12-18-5-4-10-29-25(18)33(22)14-17-7-8-17/h4-5,10-13,16-17,20H,6-9,14-15,28H2,1-3H3/t16-,20+/m0/s1

SMILES Code: O=C(C1=CC(OC)=C2C(N=C(N2C)C3=CC4=CC=CN=C4N3CC5CC5)=C1)N6[C@H](CC[C@H](C6)N)C

Solid powder

>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:

Handling Instructions:

Preparing Stock Solutions

The following data is based on the product molecular weight 472.593 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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Li M, Lin C, Deng H, Strnad J, Bernabei L, Vogl DT, Burke JJ, Nefedova Y. A Novel Peptidylarginine Deiminase 4 (PAD4) Inhibitor BMS-P5 Blocks Formation of Neutrophil Extracellular Traps and Delays Progression of Multiple Myeloma. Mol Cancer Ther. 2020 Jul;19(7):1530-1538. doi: 10.1158/1535-7163.MCT-19-1020. Epub 2020 May 5. PMID: 32371579; PMCID: PMC7335350.